Issue 54, 2016, Issue in Progress
From the journal:

RSC Advances

Base-mediated synthesis of highly functionalized 2-aminonicotinonitriles from α-keto vinyl azides and α,α-dicyanoalkenes†

Ke Shu,a   Jiaan Shao,a   Hong Li,a   Binhui Chen,a   Pai Tang,a   Xingyu Liu,a   Wenteng Chen*a  and  Yongping Yu*a  

* Corresponding authors

a Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, P. R. China
E-mail: wentengchen@zju.edu.cn, yyu@zju.edu.cn
Tel: +86-571-88208452

Abstract

A novel access to highly functionalized 2-aminonicotinonitriles via efficient annulations of α-keto vinyl azides and α,α-dicyanoalkenes is described. This annulation was achieved via base-mediated ring-openings and intramolecular rearrangements. A possible mechanism is also proposed.

Graphical abstract: Base-mediated synthesis of highly functionalized 2-aminonicotinonitriles from α-keto vinyl azides and α,α-dicyanoalkenes

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Article information

DOI
https://doi.org/10.1039/C6RA04669J
Article type
Communication
Submitted
22 Feb 2016
Accepted
26 Apr 2016
First published
27 Apr 2016

RSC Adv., 2016,6, 49123-49126

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Base-mediated synthesis of highly functionalized 2-aminonicotinonitriles from α-keto vinyl azides and α,α-dicyanoalkenes

K. Shu, J. Shao, H. Li, B. Chen, P. Tang, X. Liu, W. Chen and Y. Yu, RSC Adv., 2016, 6, 49123 DOI: 10.1039/C6RA04669J

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