One-pot four component domino strategy for the synthesis of novel spirooxindole pyrrolizine linked 1,2,3-triazoles via stereo- and regioselective [3 + 2] cycloaddition reaction in acidic medium

Abstract

An efficient, one-pot four component condensation procedure for the synthesis of selective spirooxindole pyrrolizine linked 1,2,3-triazole conjugates via [3 + 2] cycloaddition has been reported using coumarin-3-carboxylic acid (1), N-propargylated isatin (2), L-proline/sarcosine (3) and aryl azides (4) using Cu(I) as a catalyst in the presence of glacial CH₃COOH at 60 °C. The structures of the compounds synthesized herein were confirmed by ¹H NMR, ¹³C NMR, mass spectra and X-ray crystallographic techniques.