Issue 38, 2013
From the journal:

Chemical Communications

Assistant DNA recycling with nicking endonuclease and molecular beacon for signal amplification using a target-complementary arched structure†

Fenglei Gao,a   Jianping Leia  and  Huangxian Ju*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P.R. China
E-mail: hxju@nju.edu.cn
Fax: +86 25 83593593
Tel: +86 25 83593593

Abstract

A simple and universal method for ultrasensitive “signal on” detection of DNA was developed with a target-complementary arched structure to release assistant DNA, which was recycled with nicking endonuclease to amplify the detectable fluorescent signal of molecular beacons.

Graphical abstract: Assistant DNA recycling with nicking endonuclease and molecular beacon for signal amplification using a target-complementary arched structure

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Article information

DOI
https://doi.org/10.1039/C3CC40723C
Article type
Communication
Submitted
28 Jan 2013
Accepted
26 Mar 2013
First published
26 Mar 2013

Chem. Commun., 2013,49, 4006-4008

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Assistant DNA recycling with nicking endonuclease and molecular beacon for signal amplification using a target-complementary arched structure

F. Gao, J. Lei and H. Ju, Chem. Commun., 2013, 49, 4006 DOI: 10.1039/C3CC40723C

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