Issue 32, 2016
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams†

Daniel P. Canterbury,*a   Kevin D. Hespa  and  Jana Polivkovaa  

* Corresponding authors

a Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, USA
E-mail: daniel.canterbury@pfizer.com

Abstract

A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described.

Graphical abstract: Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams

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Article information

DOI
https://doi.org/10.1039/C6OB01126H
Article type
Paper
Submitted
23 May 2016
Accepted
19 Jul 2016
First published
27 Jul 2016

Org. Biomol. Chem., 2016,14, 7731-7734

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Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams

D. P. Canterbury, K. D. Hesp and J. Polivkova, Org. Biomol. Chem., 2016, 14, 7731 DOI: 10.1039/C6OB01126H

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