Palladium-catalyzed Narasaka–Heck carbonylation for the construction of functionalized ynones

Abstract

A palladium-catalyzed tandem carbonylation reaction has been developed for the construction of ynones. This reaction is characterized by readily available starting materials, broad functional group compatibility, and the use of CO as the carbonyl source. Unlike conventional carbonylation methods for synthesizing ynones, this strategy enables the efficient preparation of dialkyl chain-substituted ynones under atmospheric CO pressure. Further gram-scale experiments and derivative synthesis demonstrate the significant synthetic utility of this approach.