From the journal:

Chemical Communications

Triple-locked fluorescent probes sequentially activated by hNQO1, LAP and FA: application in bioimaging of cancer cells†

Langping Zhou,a   Han Chen,a   Weibing Zhang ORCID logo *a  and  Junhong Qian ORCID logo *a  

* Corresponding authors

a Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China
E-mail: junhongqian@ecust.edu.cn, weibingzhang@ecust.edu.cn
Fax: +86-21-64233161
Tel: +86-21-64252145

Abstract

Two fluorescent probes, subsequently activated by hNQO1, LAP and FA, were rationally designed for simultaneous detection of the above three analytes. Both probes could bioimage cancer cells overexpressing hNQO1, LAP and FA. Biotin-bearing probe NP3-Bio could discriminate between cancer cells and hypoxic normal cells.

Graphical abstract: Triple-locked fluorescent probes sequentially activated by hNQO1, LAP and FA: application in bioimaging of cancer cells

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Article information

DOI
https://doi.org/10.1039/D5CC01546D
Article type
Communication
Submitted
19 Mar 2025
Accepted
16 Apr 2025
First published
16 Apr 2025

Chem. Commun., 2025, Advance Article

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Triple-locked fluorescent probes sequentially activated by hNQO1, LAP and FA: application in bioimaging of cancer cells

L. Zhou, H. Chen, W. Zhang and J. Qian, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC01546D

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