Pd(ii)-catalyzed remote regiodivergent ortho- and meta-C–H functionalizations of phenylethylamines† †Electronic supplementary information (ESI) available: Experimental procedures and data for new compounds. CCDC 1056709 and 1406595. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01737h

A methylation switches the remote regioselectivity of C–H functionalizations of phenylethylamines.


Introduction
Controlling site selectivity is an outstanding challenge in the direct functionalization of inert C-H bonds that are ubiquitous in organic molecules. 1 The increasing applications of these type of transformations in organic synthesis also demand accessibility to diverse site selectivities. 2 While numerous directing groups have been introduced to assist the cleavage of proximal ortho-C-H bonds in most cases with transition metals, 1,3-10 directing group assisted meta-selective C-H functionalization of arenes has proved especially challenging and is still very rare. 5,6,8,9 In 2009, a remarkable breakthrough was reported by Gaunt et al., who developed a carbonyl group directed unprecedented meta-selective C-H arylation of anilides by using a Cu(II) catalyst and diaryliodonium salts. 5a This method was later extended to a-aryl carbonyl compounds by the same group. 5b Another impressive breakthrough came from the Frost group, who introduced an ingenious method of meta-selective C-H sulfonation of 2-phenylpyridines via cyclometalated ruthenium intermediates. 6a,b A similar strategy was then employed by Ackermann to realize a meta-selective C-H alkylation with secondary alkyl halides. 6c Recently, a small number of ground-breaking examples of Pd(II) catalyzed directed meta-selective C-H functionalizations of arenes that were attached with elegantly devised nitrile-based templates were disclosed, pioneered by Yu and then further studied by Tan and Maiti. 8 By using the above directing group assisted meta-selective C-H functionalization of arenes, elegant regiodivergent functionalizations of ortho-and meta-C-H bonds have been reported by Gaunt, 4b,5b Frost 6b and Yu, 8b and examples of reactions reported by Gaunt 4b,5b and Frost 6b could even be performed sequentially. 8i,11,12 However, the use of analogous directing groups to achieve remote-selective regiodivergent activation of ortho-and meta-C-H bonds has not been examined and remains a signicant challenge. 13,14 We envision that such methodology is highly desirable for drug discovery and material sciences, since it only requires a single operation to achieve a different remote regioselectivity. 2f Herein, we report a novel strategy for regiodivergent ortho-and meta-C-H functionalizations of phenylethylamine derivatives.
To test our hypothesis of a regiodivergent C-H functionalization strategy by using analogous directing groups, we selected phenylethylamines as the testing compounds, since they are a class of aromatic compounds that are important core structures of numerous drug molecules (Fig. 1). Moreover, although ortho-C-H functionalizations have been reported for phenylethylamine derivatives, their meta-selective C-H functionalization remains elusive. 15 Inspired by recent studies on directed meta-selective C-H functionalizations of arenes, 8 we proposed that a 2-cyanobenzoyl group could act as the key directing functionality for both ortho-and meta-C-H functionalizations of phenylethylamines with a Pd(II) catalyst by taking advantage of the s and p coordination ability of the nitrile group (Scheme 1). 16 However, during our study we found that our proposed mode of ortho-selective C-H bond cleavage was not feasible and a novel remote-selective ortho-C-H bond cleavage was observed instead (vide infra). 13,14 Results and discussion To examine our original hypothesis (Scheme 2), we chose ole-nation as the model reaction. 1o,17 Aer extensive condition screening with Pd(OAc) 2 as the catalyst (see ESI †), we were able to produce a high combined yield of ortho-olenated products by treating 1a with ethyl acrylate under oxygen with hexa-uoroisopropanol (HFIP) as an additive and N-acetyl-glycine (Ac-Gly-OH) ligand. 8a,18 Interestingly, the 2-cyanobenzoyl motif cyclized to an imidamide derivative in the products. To ascertain the mechanism of this olenation, 1a was subjected to the above reaction conditions without adding ethyl acrylate, affording 1a 0 that was believed to be the reactive substrate for the olenation. Indeed, aer 1a 0 was treated with the same olenation conditions, the desired products were generated in similar yields (see ESI †). Although this reaction pathway is not desired from our original hypothesis, the site selectivity of this reaction is surprisingly uncommon since the imino group of 1a 0 , the most likely directing group on 1a 0 , directed the cleavage of a remote ortho-C-H bond rather than a proximal ortho-C-H bond on the arene attached to the imidamide, which is in marked contrast to the ortho-C-H functionalizations of arylimine derivatives. 19 The exact origin of the selectivity is unclear at present, and the study of the mechanism is under way. 14 Several representative substrates were then surveyed briey (Table 1). It was found that electron-withdrawing groups like chloride and uoride were tolerated (2b-c), giving good yields of desired products. Good to excellent yields of products were also generated with substrates containing electron-donating groups such as methyl at the meta-position (2d) and methoxy at the ortho-(2e) and para-position (2f).
Having established the remote-selective ortho-C-H olenation of the secondary phenylethylamide, we were eager to test whether the selectivity could be switched to a remote-selective meta-C-H olenation aer the secondary amide is methylated into a tertiary one (see the ESI † for methylation with MeI). Starting with the above ortho-olenation reaction conditions, we were very delighted to nd that N-methyl amide 3a could lead to a 10% yield of the desired product with a trace of other regioisomers (Table 2, entry 1). Inspired by the previous discovery that HFIP was a compatible solvent with nitrile-based templates, 8 we switched the solvent to HFIP and found that the combined yield of desired products was increased dramatically to 58% with silver acetate as the sole oxidant (entry 2). Since when using weakly acidic HFIP as the sole solvent some substrate might decompose, DCE was added as the co-solvent, resulting in an increased yield of 73% (entry 3). To optimize the solvent system, we decreased the volume of HFIP to 15% and found that the combined yield was only slightly improved (entry 4). However, a further decreased volume of HFIP led to a much diminished yield (entry 5). Other solvents were also screened, but the combination of DCE and HFIP proved to be the best. The addition of a weak base, such as KHCO 3 , to tune the acidity of the reaction system was not effective either (entry 6). Since a higher catalytic turnover of the Pd catalyst was observed with 50% volume of HFIP, we repeated the reaction with this solvent system at 80 C and found that the combined yield was improved to 90% in 32 hours under nitrogen (entry 7), representing the highest catalytic turnover of the Pd catalyst. Finally, by adding 5 equivalents of DMF we were able to get more mono-olenated product in 28 hours while maintaining the overall efficiency (entry 8, see the ESI † for more condition screenings). However, further screening of reaction conditions could not result in better mono-vs. di-olenation selectivity at present, Fig. 1 Representative drugs containing a phenylethylamine core.
With the optimized conditions at hand, we examined the scope of this remote meta-selective olenation protocol (Table  3). Ortho-substituted substrates with both electron-donating methyl and methoxy and electron-withdrawing bromo and chloro groups proved to be suitable substrates, producing good combined yields of meta-olenated products (4b-4e). It is worth noting that arenes bearing bromo or chloro substituents (4d and 4e) were compatible substrates, enabling further elaboration at the halogenated positions. Moreover, although we could not circumvent di-olenation (4b, 4d-e), the fact that both metapositions of 2-substituted substrates could be functionalized provides a great opportunity for synthesis of diversely substituted arenes, which is particularly benecial for the drug discovery industry. The remaining meta-position of metasubstituted substrates was also selectively olenated in high yields (4f-4i). Para-substituted compounds carrying methoxy or halide groups were also viable substrates for obtaining high yields of the desired products (4j-4l). Notably, despite the steric hindrance, the olen partner could also be installed selectively at the meta-position with poly-substituted substrates (4m-4n), displaying an uncommon procedure for constructing new penta-substituted phenylethylamines. It is interesting to note that the reaction was not sensitive to the difference of steric hindrance and both meta-positions of 3n could be olenated. Finally, substituents at the benzylic position were also tolerated (4o and 4p), presenting the potential utility of this protocol with a drug molecule (4p). The meta-selectivity of various substrates was generally excellent with only minor amounts of other isomers whose amounts were hard to determine due to the presence of rotamers in the 1 H NMR spectra of the crude ole-nated products. The exceptional substrate is 3g, which also generated around 10% of other isomeric products owing to the electron-donating methoxy substituent. However, it is notable that the intrinsic electronic biases of the molecules were overall successfully overridden (4d-4f, 4k-4n). Moreover, removal of the directing group was smoothly realized by hydrolysis with HCl to afford high yields of new meta-substituted phenylethylamines (see the ESI †).
To further expand the scope of this reaction, we examined various olen coupling partners and found olenation of 3f with a,b-unsaturated ketone, amide and phosphonate afforded desired products in good yields ( Table 4, 6a-6c). We were also pleased to nd trans-2-butenoate reacted stereoselectively with 3f to give 6d in moderate yield. It is noteworthy that this reaction was also compatible with cyclic tri-substituted olen to give high yield of allylated product (6e). Finally, electron decient  styrene such as pentauorostyrene 5f was also effective with this method to produce excellent yield of product (6f), albeit electron-rich styrenes were not applicable coupling partners. Finally, to demonstrate the potential of our method for streamlined synthesis of highly substituted arenes, we rst subjected 1c to our standard ortho-olenation conditions with 5f and obtained ortho-olenated 7 in 86% yield (Scheme 3). Then, much to our delight, we were able to convert 7 to the desired amide 8 with the required nitrile group which was reconstructed simultaneously with methylation by using LiHMDS, followed by hydrogenation of the double bond. 20 Lastly, the meta-selective allylation proceeded efficiently with tri-substituted olen 5e to afford tetrasubstituted arene 9 in good yield, enabling the building of complexity in a concise manner.

Conclusions
In summary, a novel example of remote regiodivergent orthoand meta-C-H functionalizations has been developed with phenylethylamine derivatives by introducing a novel 2-cyanobenzoyl group as the original directing functionality. A single methylation was sufficient to switch the remote regioselectivity. This method also enabled the novel sequential functionalizations of ortho-and meta-C-H bonds of a phenylethylamine derivative. Further development of this strategy will improve C-H functionalization to become a more versatile synthetic tool.