Iron catalyzed CO2 hydrogenation to formate enhanced by Lewis acid co-catalysts

Iron/Lewis acid co-catalysts hydrogenate to CO2 to formate with unprecedented turnover for a first row transition metal catalyst.


Introduction
The increasing volatility in price and the negative environmental impact associated with fossil fuel utilization for energy and commodity chemical production continues to spur basic research into the exploitation of renewable carbon resources. 1 CO 2 is an attractive target for transitioning the chemical industry to sustainable feedstocks, due to its incredible abundance, cheap availability and low toxicity. 2 Formic acid is an especially interesting CO 2 reduction product given its use in numerous agrochemicals and preservatives, 3 as well as its potential role as a material for chemical hydrogen storage (CHS) in renewable energy applications. 4 The utilization of formic acid as a CHS material requires reversible hydrogenation/dehydrogenation between CO 2 and formic acid, a reaction with a small thermodynamic preference (7 kcal mol À1 ) toward CO 2 and H 2 in the gas phase. 5 Consequently, most catalysts for the hydrogenation of CO 2 to formic acid rely on exogenous base to form formate, which drives the reaction. 6 The most effective of these catalysts employ precious metals such as ruthenium, 7 rhodium, 8 and iridium, 9 and turnover numbers (TONs) of approximately 3.5 Â 10 6 and turnover frequencies (TOFs) near 150 000 h À1 have been achieved at elevated pressures and temperatures (49-59 atm; 120-220 C). 10 These ndings demonstrate the remarkable potential for catalytic CO 2 hydrogenation to formate, but also motivate the development of earth abundant catalytic systems, which are expected to enhance the sustainability and economic feasibility of this transformation.
Although homogeneous catalysts for CO 2 hydrogenation to formate containing rst-row transition metals were rst described in 1976, 11 TONs were low. As a result for many decades signicantly more attention was devoted to the study of heterogeneous catalysts containing rst-row transition metals. 12 However, in recent years, the development of homogenous catalysts has been reinvigorated by the discovery of several more active cobalt and iron based systems. 13 For example, Fujita et al. reported a Cp*Co (Cp* ¼ h 5 -C 5 Me 5 ) complex supported by a dihydroxy-bipyridine ligand that is capable of 59 turnovers to formate in aqueous bicarbonate, 14 while Linehan and coworkers described an even more impressive TON of 9400 using (Me 2 PCH 2 CH 2 PMe 2 ) 2 CoH, although the use of a costly and strong base (Verkade's base) is required for high conversion. 15 During the same time period, Beller and coworkers described both cobalt and iron catalysts supported by tetraphosphine ligands, with the [P(o-C 6 H 4 PPh 2 ) 3 Fe] 2+ congener affording the highest TON for an iron catalyst to date. 16 This in situ generated system afforded 1897 turnovers to formate in methanol/water with excess NEt 3 under 60 atm of CO 2 /H 2 at 100 C. 16b Another noteworthy iron system was reported by Milstein and coworkers who showed that a complex supported by pincer ligand with a pyridine backbone could give 708 turnovers under remarkably mild pressures (8-10 atm) in 2 M aqueous NaOH. 17 Collectively these discoveries establish that earth abundant metals are capable of promoting CO 2 hydrogenation, but their activities lag far beyond those of precious metal catalysts.
Our laboratories recently identied iron catalysts for formic acid dehydrogenation (FADH), the reverse of CO 2 hydrogenation, which surpass even precious metal catalysts in activity. 18 The iron(II) formate carbonyl hydride species, ( R PNP)Fe(H) CO(HCO 2 ) ( R PNP ¼ HN{CH 2 CH 2 (PR 2 )} 2 ; R ¼ i Pr (HCO 2 -1a), R ¼ Cy (HCO 2 -1b)), bearing a bifunctional amine ligand give 1 Â 10 6 turnovers for FADH with a TOF near 200 000 h À1 (Fig. 1). Slightly diminished performance was also observed using the ve-coordinate iron(II) species, (( R PNP)Fe(H)CO; R ¼ i Pr (1a), R ¼ Cy (1b)), which readily form HCO 2 -1a and HCO 2 -1b upon exposure to formic acid. The impressive activity is dependent on the presence of a Lewis acid (LA) co-catalyst, such as LiBF 4 , which preliminary mechanistic studies indicate aids in the decarboxylation of an iron-formate intermediate. Herein we report the development of a collection of iron complexes based on this PNP ligand motif, which catalyze the hydrogenation of CO 2 to formate with TONs approaching 60 000, far greater than any previously described earth abundant metal catalyst. These high TONs are only achieved in the presence of a LA co-catalyst and we describe detailed mechanistic studies which elucidate the crucial role of the LA.

Results and discussion
CO 2 hydrogenation activity of ( R PNP)Fe(H)CO The mildly endergonic prole of CO 2 hydrogenation to formic acid has led researchers to employ a wide variety of exogenous bases to drive this reaction. Given the limited stability of 1a and 1b in aqueous environments, 19 our initial catalytic experiments focused on identifying suitable bases with moderate to good solubility in organic solvents. A brief screen of bases using 1b in THF and a combined 69 atm of CO 2 /H 2 (1 : 1) at 80 C indicated that Cs 2 CO 3 and 1,8-diazabicycloundec-7-ene (DBU) were among the most effective bases in promoting formate production (Table S1 †). For subsequent investigations, DBU was selected as the base of choice owing to its higher solubility in THF and moderately better TON compared to Cs 2 CO 3 . The TON of 78 observed using DBU indicates that 1b is, at best, a modest catalyst for CO 2 reduction by itself. However, addition of LiBF 4 dramatically improved the conversion. 20 Conducting catalytic reactions using 1a and 1b in the presence of a LA (2 : 1 ratio of DBU : LiBF 4 ) afforded a ca. 3-4 fold increase in TON, with the -PCy 2 substituted 1b showing a slightly higher conversion (Table 1). A screen of LiBF 4 loadings between DBU : LiBF 4 ratios of 150 : 1 to 2 : 1 showed an onset of saturation behavior below 6 : 1 (Table S2 †), thus a DBU : LA ratio of 7.5 : 1 was employed as the benchmark co-catalyst loading for most catalytic experiments reported here. This loading balances the higher conversions at increased LA loadings with possible complications arising from solubility limitations.
In our previous work on LA enhanced FADH we screened a large range of Lewis acidic salts and identied LiBF 4 as the optimum co-catalyst. 18 A more limited examination of LAs was conducted for the CO 2 -to-formate reaction with an emphasis on using readily available alkali metal salts (Table 2). Entries 2-4 show the superior performance of the  triuoromethanesulfonate anion (OTf À ) compared to BF 4 À or Cl À . In the case of Cl À , an inhibition of the reaction compared to no added LA was observed, likely due to coordination of Cl À to the iron catalyst. Additional comparison of the three lightest alkali metal OTf salts (entries 4-6) indicated good TON for all species, with a slightly higher conversion for the Li cation. The incongruous reaction conditions employed across most iron and cobalt catalyzed CO 2 hydrogenation reactions make a denitive comparison of catalyst activity challenging. The ca. 3000 TON observed for the LiOTf/1b catalyzed CO 2 -to-formate reaction ( Table 2; entry 4) is higher than any other iron mediated system to date and it functions under comparable reaction conditions to the [P(o-C 6 H 4 PPh 2 ) 3 Fe] 2+ catalyst described by Beller. 16b The LA/Fe co-catalyzed reaction is also far more active than cobalt catalysts when DBU is employed as the common base, although higher TONs are achieved with cobalt under different reaction conditions. 15

Synthesis and characterization of [ R PN Me PFe] complexes
A potentially important feature of 1 is that it can undergo reactions in which there is metal-ligand cooperation 21 due to the ability of the PNP ligand to be in either a protonated or deprotonated form. 18,19,22 Beller and coworkers have recently reported the synthesis of MeN{CH 2 CH 2 (P i Pr 2 )} 2 and its coordination to iron as part of control experiments relating to catalytic nitrile and ester hydrogenation. 23 To further explore the role of the bifunctional ligand we were interested in comparing the activity for CO 2 hydrogenation of iron complexes supported by both R PN H P and R PN Me P ligands. In our hands both the isopropyl and cyclohexyl versions of R PN Me P were coordinated to FeCl 2 by stirring in THF solution to give excellent yields of ( R PN Me P)FeCl 2 (Fig. 2). Each species displays a set of broad peaks between ca. À5 and 75 ppm in the 1 H NMR spectrum, indicative of a paramagnetic substance. The molecular structure of ( iPr PN Me P)FeCl 2 was conrmed by X-ray diffraction (Fig. S16 †) and exhibited a distorted square pyramidal geometry (s ¼ 0.37). 24 Treatment of these iron(II) dichloride species with sodium borohydride in MeCN/EtOH afforded the six-coordinate ( R PN Me P)Fe(H)BH 4 species (Fig. 2). The structure of the P i Pr 2 congener was characterized by X-ray diffraction as depicted in Fig. S17. † The data were of sufficient quality that all hydrogen atoms, including those bound to iron and boron, were located in the difference map and clearly indicate a k 2 -coordination of the BH 4 ligand.
The ( R PN Me P)Fe(H)BH 4 species each react readily with 1 atm of CO to yield ( R PN Me P)Fe(H)CO(BH 4 ) (R ¼ i Pr (3a), R ¼ Cy (3b)) as yellow compounds (Fig. 2). The highest purity materials were obtained from syntheses conducted in pentane over short reaction times (30-45 minutes). 1 H NMR spectra of 3a and 3b in benzene-d 6 each display an iron-hydride resonance near À20 ppm and a very broad borohydride signal around À2.5 ppm. The broad resonance of the BH 4 fragment is typical of k 1 -coordinated species and suggests a rapid interchange of the bound B-H bond on the NMR timescale. 25 The P i Pr 2 congener, 3a, again provided a solid state structure from X-ray diffraction This journal is © The Royal Society of Chemistry 2015 experiments ( Fig. S18 †), which conrms the k 1 -coordination of BH 4 and the binding of CO ligand trans to the tertiary amine. The thermal stability of 3a in benzene or THF was limited. Even upon standing under an N 2 atmosphere for 1 hour, new Fe-H resonances began to appear in the 1 H NMR spectrum. These resonances, along with signals in the 31 P NMR spectrum, are consistent with those previously described by Beller and coworkers for the cis and trans dihydride isomers of ( iPr PN Me P) Fe(H) 2 CO (4a). 23, 26 The conversion of 3a to 4a appears to be inuenced by solvent and exposure to vacuum, with use of THF and lower pressures enhancing formation of the iron(II) dihydride species. Pure samples of 4a were obtained by treatment of 3a with a large excess of NEt 3 and crystallization from pentane at low temperature. Crystal samples of 4a obtained at À30 C consistently afforded a molecular structure of the cis dihydride isomer (Fig. S19 †), including characterization of two polymorphs of the material. 27 However, solutions prepared from the crystalline material consistently show a 3 : 1 ratio favoring the trans dihydride isomer. EXSY NMR experiments (mixing time 800 ms at 22 C) do not display correlations indicative of rapid isomer interconversion on the NMR timescale, but the consistent ratio from multiple samples suggests isomerization likely occurs over longer time periods.
The addition of 1 atm of CO 2 to 4a generated the iron formate complex 5a as a 5 : 1 mixture of two isomers (Fig. 2). The major isomer of 5a exhibits an Fe-H resonance at À23.89 ppm ( 3 J P-H ¼ 52 Hz) and a formate C-H peak at 9.22 ppm in the 1 H NMR spectrum along with a signal at 84.81 ppm in the 31 P { 1 H} NMR spectrum. The minor isomer displays similar resonances, which are illustrated in the ESI. † A structural assignment of the isomers of 5a was based on a combination of 2D NOESY, 13 CO isotopic labeling and X-ray diffraction experiments. Cooling a diethyl ether solution of 5a to À35 C yielded small yellow needles which weakly diffracted X-rays. While the data was marginal (requiring all hydrogens not bound to iron to be calculated) the renement did afford a satisfactory solution with the molecular structure depicted in Fig. S20. † The crystallized isomer of 5a contains a meridional chelate ligand with the formate moiety positioned proximal to the N-Me substituent. The Fe-H bond is located trans to the formate ligand and cis to the iron-carbonyl. Additional structural evidence was obtained from 2D NOESY NMR spectra (23 C, 300 ms mixing time) which indicated a through space correlation between the Fe-H and N-CH 3 resonances for at least one of the isomers of 5a, though overlap between the isomers obviated assignment for this correlation to a specic isomer. Still, the NOESY NMR data indicated that the Fe-H and N-CH 3 fragments are on the same face of the iron coordination environment for one isomer, presumably the one not identied by X-ray diffraction. 28 Isotopic labeling of 5a with 13 CO afforded 2 J C-H coupling constants between the bound 13 CO and Fe-H of 19.5 and 23.9 Hz for the major and minor isomers, respectively. The larger coupling constant for the minor isomer indicates a trans disposition of these fragments, which along with the NOESY NMR data and X-ray diffraction study is consistent with the isomers depicted in Fig. 2. This collection of data also suggests the structure determined by X-ray diffraction is the major isomer.

CO 2 hydrogenation activity of [ R PN Me PFe] complexes
With several [ R PN Me PFe] complexes in hand, the metal-hydride containing species ( iPr PN Me P)Fe(H)BH 4 , 3a and 4a were each screened for CO 2 hydrogenation under the conditions described for 1b/LiOTf in Table 2. Although ( iPr PN Me P)Fe(H)BH 4 proved to be an ineffective catalyst with a TON ¼ 52 (a conversion comparable to the reaction without iron catalyst), both 3a and 4a afforded very high conversions with TONs of 7660 and 6900, respectively (Table 3). The observed formate yields were in excess of the equivalents of DBU employed; however, stabilization of multiple formate ions by a single DBU via homoconjugation has been previously observed. 15b,29 The dramatic improvement in catalyst performance using the N-methylated ligand necessitated trials at lower catalyst and higher DBU loadings to better elucidate their optimum performance. Given the comparable activity of 3a and 4a in preliminary experiments, the relative ease in obtaining 3a made it a more convenient choice for exploratory catalytic trials (Table 3). Only when the catalyst loading was dropped to 0.30 mmol and the DBU/Fe ratio raised to ca. 40 000 did the yield of formate decrease below the concentration of DBU employed. At ca. 80 000 equivalents of base per iron an impressive 42 347 turnovers to formate were observed. Further enhancement of the conversion to nearly 60 000 TON was achieved by raising the LiOTf co-catalyst loading to 5/1 with base, however, at this loading not all of the LiOTf appeared to dissolve and further increasing LiOTf amounts did not enhance the conversion. The central role of the LA co-catalyst was demonstrated in a control experiment where the absence of LiOTf drops the TON to a meager 2790. Overall, this remarkably active catalyst system affords TONs more than an order of magnitude greater than any previously reported iron catalysts. Table 4 provides a comparison of each of the iron CO 2 hydrogenation catalysts described herein. 30 Each trial was conducted under 69 atm of CO 2 : H 2 (1 : 1) with 0.30-0.78 mmol catalyst, and 79 600 equiv. of DBU with a 7.5 : 1 loading of base to LiOTf in THF at 80 C. Under these conditions the secondary amine containing complexes 1a and 1b (entries 2 and 3) improve their TONs to 6030 and 8,910, respectively, over 24 hours. Trials conducted at longer reaction times did not improve the conversion indicating the catalysts had completely deactivated aer 1 day. Use of the borohydride analog, ( iPr PNP)Fe(H)CO(BH 4 ) (2a), a feasible precatalyst for 1a, showed dramatically lower activity (entry 3). 25c While the secondary amine [ R PNPFe] complexes are highly active catalysts with respect to most previously reported iron and cobalt catalysts, they pale in comparison to the tertiary amine [ R PN Me PFe] systems. As noted above, 3a delivers a remarkable 42 350 conversions to formate over 24 hours (entry 4). Much like the analogous secondary amine supported catalyst, the cyclohexyl phosphine substituted 3b (entry 5) offers a small enhancement over the isopropyl phosphine counterpart. Use of the iron(II) dihydride carbonyl species 4a in place of the borohydride precursor (entries 4 and 6) afforded very similar TONs and TOFs (TOF were measured aer the rst hour of reaction). This is consistent with a rapid conversion of 3a to 4a under catalytic conditions, with both species then proceeding via a common mechanism for CO 2 hydrogenation (vide infra). 1 Use of 5a as a catalyst (entry 7) gave activity comparable to 3a and 4a, consistent with it being an intermediate in catalysis using 3a or 4a. It is notable that for all the [ R PN Me PFe] catalysts (entries 4-7) almost half the total conversion occurs during the rst hour of the reaction. Again, no additional conversion was observed for experiments conducted for longer than 24 hours. This is indicative of highly active catalysts whose overall productivity declines signicantly as the reaction proceeds.

Mechanistic considerations of ( R PNP)Fe(H)CO/Li + catalyzed CO 2 hydrogenation
We were interested in understanding the role of the LA in systems supported by both R PNP and R PN Me P ligands and the increased activity of the tertiary amine supported species. The rate inuencing role of the LA co-catalyst was rst explored by studying the elementary reaction steps in isolation via NMR spectroscopy in systems with the bifunctional R PNP ligand. On the basis of our related studies, 18 a plausible pathway for CO 2 hydrogenation starting from 1 could proceed via (1) 1,2-addition of H 2 across the Fe-N bond, followed by (2) insertion of CO 2 into an Fe-H, and then (3) N-H deprotonation accompanied by formate extrusion to regenerate 1 (Scheme 1). Since the activities of 1a and 1b were comparable, -P i Pr 2 substituted 1a was selected for NMR experiments due to its simplied spectra.
The H 2 activation reaction can be observed directly by addition of H 2 to 1a in THF or benzene solution, and results in near instantaneous bleaching of the dark red color and a corresponding appearance of NMR signals previously described for ( iPr PNP)Fe(H) 2 CO (H 2 -1a). 18 Though H 2 -1a was not isolable in the absence of an H 2 atmosphere, CO 2 insertion was immediately observed upon addition of 1 atm of CO 2 to an in situ generated solution of H 2 -1a (Fig. 3). Careful examination of the NMR spectra over the rst 15 minutes following CO 2 addition revealed sufficient signals to account for the formation of two products. Two triplet Fe-H resonances were observed in the 1 H NMR spectrum, at À25.43 and À25.83 ppm and 31 P NMR spectra exhibited peaks at 95.40 and 93.99 ppm. The more upeld resonance in each of these pairs was assigned to HCO 2 -1a, which was previously prepared by addition of formic acid to 1a. 18 Over the course of 1 hour the resonances originating from the second product diminished with concomitant growth in the signals for HCO 2 -1a. The reaction sequence was repeated using 13 CO 2 in order to gain insight into the transient product which afforded two enhanced resonances in the 13 C NMR spectrum at 165.37 and 174.81 ppm. 1 H-13 C HSQC NMR spectra showed correlation between the resonance at 174.81 ppm and the formate C-H resonance of HCO 2 -1a at 9.51 ppm in the 1 Hdimension; however, no one-bond correlations were observed for the signal at 165.37 ppm. This indicated that the transient species was not simply an isomer of HCO 2 -1a. Instead complex CO 2 -1a is the formal product of CO 2 addition across the Fe-N bond, and separate experiments show that this species may also be obtained as the sole product from the reaction of CO 2 to 1a. Denitive characterization of CO 2 -1a was established by single crystal X-ray diffraction as depicted in Fig. S21. † To the best of our knowledge, addition of CO 2 across an Fe-NR 2 bond has not previously been reported, but the transformation is closely related to the more commonly observed cycloaddition of CO 2 to transition metal imides and CO 2 insertion into transition metal amides. 31 Though CO 2 -1a has limited stability to vacuum, small quantities of pure material were isolated by low temperature crystallization from pentane solution under N 2 . Notably, addition of 1 atm of H 2 to CO 2 -1a affords HCO 2 -1a cleanly over 6-8 hours at ambient temperature with no observable intermediates. If these results are extrapolated to the catalytic conditions, this suggests that formation CO 2 -1a is likely of minimal consequence to CO 2 hydrogenation, but may serve as a reversibly formed off-cycle catalytic intermediate. Overall, the rapidity of H 2 -1a and HCO 2 -1a formation (even under temperature and pressure conditions far more mild than the catalytic reaction) suggests that extrusion of formate and/or N-H deprotonation from HCO 2 -1a are likely key to the rate of ( R PNP)Fe(H)CO/Li + catalyzed CO 2 hydrogenation. This was supported by in situ NMR spectroscopy of a catalytic reaction under modied conditions (1 : 3 : 40 ratio of HCO 2 -1a:LiBF 4 : DBU in THF under 2 atm of CO 2 /H 2 at ambient temperature) which showed 31 P and 1 H NMR resonances approximate to HCO 2 -1a as the primary organometallic species. To better assign these resonances and gain further insight into roles of Fe, Li + and DBU in this portion of the reaction, a series of stoichiometric NMR scale reactions was performed (Fig. S1 †).
First, samples of HCO 2 -1a were independently treated with 1 equiv. of DBU and LiBF 4 in THF-d 8 . The sample treated with base showed no reaction, but the NMR spectra of the sample containing LA exhibited several changes indicative of an interaction between HCO 2 -1a and Li + . LiBF 4 addition resulted in a $1.5 ppm upeld shi of the 31 P NMR resonance and a corresponding downeld shi of $0.2 ppm for the Fe-H peak in the 1 H NMR spectrum (Fig. S1 †). A more dramatic upeld movement of the N-H resonance from 8.52 to 5.74 ppm was also observed. This change in chemical shi is consistent with a disruption of the hydrogen bonding interaction between the secondary amine and the bound formate, an interaction which has been predicted by computational analysis. 18,19 While an exact structure for the Li-bound HCO 2 -1a complex has not been established, 7 Li NMR spectroscopy exhibited a resonance at À2.12 ppm which is consistent with a Li-O interaction. 32 Subsequent addition of 1 equiv. of DBU to the Li + /HCO 2 -1a complex produced only a minimal change in the 31 P NMR spectrum, and a very modest shi of the N-H proton resonance back downeld to 6.20 ppm. This indicates that DBU does not signicantly alter the hydrogen bonding interaction. Notably, no conversion to 1a and free formate was detected by NMR spectroscopy.
The stoichiometric experiments suggest a three component equilibrium exists between HCO 2 -1a, Li + /HCO 2 -1a, and DBU/ Li + /HCO 2 -1a complexes (Fig. 4). The inability to observe separate NMR resonances for these species (even at À80 C) suggests that equilibration is rapid. The relative upeld N-H 1 H NMR chemical shi also indicates a thermodynamic preference for the Li + /HCO 2 -1a and DBU/Li + /HCO 2 -1a complexes. However, it is important to consider that the conditions of these stoichiometric NMR experiments are far removed from the prevailing Li + and DBU concentrations under catalytic conditions.
In order to better model the catalytic reaction a J. Young NMR tube was charged with DBU/LiBF 4 /HCO 2 -1a in a 40 : 3 : 1 ratio. Initial NMR spectra were nearly identical to those for the stoichiometric DBU/Li + /HCO 2 -1a mixture (Fig. S2 †). Addition of Scheme 1 Proposed mechanism for ( R PNP)Fe(H)CO/Li + catalyzed CO 2 hydrogenation. 1.5 atm each of H 2 and CO 2 produced a gradual downeld shi in the N-H resonance along with the growth of a new peak near 9.30 ppm assigned to the free formate product. Aer 2 hours the conversion was complete and the N-H resonance remained at $7.80 ppm. This experiment is consistent with a reaction model where the initial resting state of the catalyst is dominated by the Li + and DBU bound forms of HCO 2 -1a, but as DBU is consumed and the product ammonium formate reduces the available Li + concentration via equilibration between the salts, the resting state equilibrium shis toward the pure HCO 2 -1a complex.
Overall, the combination of data collected from the NMR experiments point toward the extrusion of formate from iron and/or the deprotonation of the N-H bond as the limiting steps of ( R PNP)Fe(H)CO/Li + co-catalyzed CO 2 hydrogenation. The addition of LA appears to enhance catalysis primarily by assisting removal of the anionic formate and making the N-H fragment more available for DBU deprotonation through disruption of its hydrogen bond.

Mechanistic considerations for [ R PN Me PFe] catalysts
The mechanism of CO 2 hydrogenation for the [ R PN Me PFe] catalysts was investigated through a series of NMR spectroscopy experiments. The similar catalytic performance of the iron borohydride and dihydride catalysts, 3a and 4a (Table 4), as well as the synthesis of 4a from 3a in the presence of base, suggests that both catalysts function via the same mechanism. It is likely that 3a simply serves as a precatalyst, which rapidly forms 4a upon exposure to the high concentrations of DBU present at the initiation of the reaction. This hypothesis was supported by in situ monitoring using NMR spectroscopy of a catalytic reaction using 3a or 4a with 3 and 40 equiv. of LiBF 4 and DBU, respectively, under 1.5 atm each of H 2 and CO 2 (Fig. S3-S6 †). In both cases, catalytically active ( iPr PN Me P)Fe(H)CO(HCO 2 ) (5a) (see Table 4), was observed as the resting state during formate production, although some residual 3a remained in the experiment using the iron borohydride catalyst.
The iron formate catalyst resting state for the [ R PN Me PFe] systems parallels that observed for the secondary amine complexes, suggesting that formate extrusion still limits the rate of catalysis. In the case of 1a and 1b, our mechanistic experiments demonstrated that the Li + co-catalyst assisted with this step, in part, by disrupting an intramolecular hydrogen bond between the formate and amide ligand. The role of Li + was similarly probed for the [ R PN Me PFe] system through stoichiometric NMR experiments. A sample of 5a in THF-d 8 was rst treated with 5 equiv. of DBU under 1 atm H 2 and monitored for 16 hours at ambient temperature, resulting in no observable formation of free formate or the iron dihydride complex 4a. However, addition of 3 equiv. of LiBF 4 immediately afforded full conversion to 4a and extrusion of a formate ion (Fig. S12 and S13 †). This observation is consistent with LA assistance of formate release from the iron coordination sphere, likely via stabilization of the anionic formate by the Li + center. Further evidence for this interaction was obtained by the addition of 3 equiv. of LiBF 4 to a THF-d 8 solution of 5a, which immediately shied the Fe-H 1 H NMR resonances upeld by approximately 0.5 ppm and dramatically broadened both these signals and the peaks corresponding to the formate C-H protons. A broadening and upeld shi of signals was also observed in the 31 P NMR spectrum, suggestive of a reversible coordination of Li + to 5a ( Fig. S14 and S15 †).
The mechanistic information available suggests a pathway for [ R PN Me PFe] catalyzed CO 2 hydrogenation which shares some common features with the secondary amine containing [ R PNPFe] catalyst (Scheme 2), including the insertion of CO 2 into an Fe-H bond followed by rate limiting formate extrusion. Yet the absence of a bifunctional amide moiety requires distinct mechanisms for the elementary reaction steps of H 2 activation and deprotonation by DBU. It is proposed that for the [ R PN Me PFe] catalysts, Li + facilitates the displacement of formate by dihydrogen to generate a transient iron(II) dihydrogen cationic complex, which is then deprotonated by DBU to regenerate the iron(II) dihydride species. No spectroscopic evidence for the iron(II) dihydrogen cationic complex has been observed during catalysis, but several closely related iron complexes have been observed by others and implicated as intermediates in CO 2 hydrogenation. 3d,13a,33 Given the prior precedent, a formate release/H 2 deprotonation sequence was deemed more likely than an Fe-H deprotonation/H 2 oxidative addition pathway, which would require the intermediacy of a zerovalent iron species.

Conclusions
The catalytic activity of a family of PNP supported iron hydrides, containing either secondary or tertiary amines was investigated. In both cases dramatic improvements in TON and TOF were observed when LA co-catalysts were present. Our best system, involving the tertiary amine supported complex ( iPr PN Me P)Fe(H) CO(BH 4 ), achieved approximately 60 000 turnovers, more than an order of magnitude greater than other iron catalysts and far superior to any earth abundant metal catalysts reported to date. In systems containing a secondary amine ligand, NMR spectroscopy identied the catalyst resting state as ( R PNP)Fe(H) CO(HCO 2 ) and suggested a key role for LA was disrupting a stabilizing hydrogen bond between N-H and Fe-O 2 CH moieties in this species. Mechanistic consideration of the [ R PN Me PFe] catalysts afforded a model whereby ( R PN Me P)Fe(H)CO(BH 4 ) was activated by base to produce a ( R PN Me P)Fe(H) 2 CO species which rapidly inserts CO 2 . The resulting formate complex, ( iPr PN Me P) Fe(H)CO(HCO 2 ), was identied as the catalytic resting state. In this case, the primary role of LA was its assistance in a formate for dihydrogen substitution which yields a transient cationic iron(II) dihydrogen complex. Subsequent deprotonation of the dihydrogen fragment by DBU regenerates ( R PN Me P)Fe(H) 2 CO. This pathway for CO 2 hydrogenation resulted in remarkable activity, providing approximate TOFs of 20 000 h À1 . Given that most precious and earth abundant metal catalysts are postulated to operate via similar mechanisms for CO 2 hydrogenation, it is possible that the use of LA co-catalysts could dramatically enhance performance across of a range of other CO 2 reduction systems. Such improvements in CO 2 hydrogenation at iron may enable these or related catalyst systems to produce even higher value products, such as methanol, under optimized conditions. Targeting these CO 2 functionalization products, as well as further elucidating the structure-reactivity relationships in the [ R PN Me PFe] system are the foci of on-going efforts in our laboratories.