Issue 4, 2015

Pd(ii)-catalyzed asymmetric addition of arylboronic acids to cyclic N-sulfonyl ketimine esters and a DFT study of its mechanism

Abstract

A palladium-catalyzed asymmetric arylation of cyclic N-sulfonyl ketimine esters is described. The desired products could be prepared with excellent yields (up to 99%) and enantioselectivities (up to 99% ee) under mild reaction conditions. Furthermore, a possible reaction mechanism was determined using DFT calculations.

Graphical abstract: Pd(ii)-catalyzed asymmetric addition of arylboronic acids to cyclic N-sulfonyl ketimine esters and a DFT study of its mechanism

Supplementary files

Article information

Article type
Research Article
Submitted
23 Dec 2014
Accepted
09 Feb 2015
First published
11 Feb 2015

Org. Chem. Front., 2015,2, 398-402

Author version available

Pd(II)-catalyzed asymmetric addition of arylboronic acids to cyclic N-sulfonyl ketimine esters and a DFT study of its mechanism

M. Quan, G. Yang, F. Xie, I. D. Gridnev and W. Zhang, Org. Chem. Front., 2015, 2, 398 DOI: 10.1039/C4QO00347K

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