An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics

Qi Wang; Ruoqing Wang; Xiaoyuan Wang; Mingxuan Fu; Yicong Gao; Jianfeng Feng; Renyong Geng; Zhen Yuan; Quli Fan; Feng Lu

doi:10.1039/D4CC00431K

An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics†

Qi Wang,

^a Ruoqing Wang,^a Xiaoyuan Wang,^a Mingxuan Fu,^a Yicong Gao,^a Jianfeng Feng,^a Renyong Geng,*^b Zhen Yuan,

^c Quli Fan

^a and Feng Lu

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
E-mail: iamflu@njupt.edu.cn

^b School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, China
E-mail: renyonggeng@fynu.edu.cn

^c Faculty of Health Sciences and Center for Cognitive and Brain Sciences, University of Macau, Macau 999078, China

Abstract

A small molecule-based NIR-II type-I photosensitizer (IT-IC) with a strong push–pull effect and good planar π-conjugated structure was synthesized. The IT-IC NPs exhibited strong light absorption, outstanding NIR-II fluorescence emission, excellent photothermal conversion and efficient type-I/II ROS generation, showing encouraging therapeutic outcomes for hypoxic tumors.

Chemical Communications

An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics†

Abstract

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An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics

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