One-pot quadruple/triple reaction sequence: a useful tool for the synthesis of natural products

Abstract

Multiple reactions in one pot has always been a useful technique for synthetic organic chemists, as it can minimizes solvent usage, time and the number of purification steps when compared to individual multi-step syntheses. In line with this, here in this perspective we discuss a one-pot quadruple/triple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels–Alder/aromatization for the synthesis of natural products setting.