From the journal:

Chemical Communications

A high affinity and selective DNA aptamer for copper ions†

Jin Wang,ab   Yibo Liu,b   Xiangmei Li, ORCID logo a   Hongtao Lei ORCID logo *a  and  Juewen Liu ORCID logo *b  

* Corresponding authors

a Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China
E-mail: hongtao@scau.edu.cn

b Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
E-mail: liujw@uwaterloo.ca

Abstract

Capture-SELEX was employed for the selection of DNA aptamers for Cu2+. The best aptamer named Cu-1 has a Kd of 14.2 nM as determined using the strand-displacement assay, representing an approximate 3000-fold improvement over a previously reported Cu2+ aptamer. The sensor achieved a limit of detection of 2.1 nM.

Graphical abstract: A high affinity and selective DNA aptamer for copper ions

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Article information

DOI
https://doi.org/10.1039/D4CC05410E
Article type
Communication
Submitted
12 Oct 2024
Accepted
05 Nov 2024
First published
05 Nov 2024

Chem. Commun., 2024, Advance Article

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A high affinity and selective DNA aptamer for copper ions

J. Wang, Y. Liu, X. Li, H. Lei and J. Liu, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC05410E

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