Suppressing hydrodechlorination in PC–Ni cocatalyzed C–N and C–O coupling reactions

Abstract

In the preparation of N-arylation products via C–N coupling reactions using haloarenes, dehalogenation side reactions frequently occur. This study demonstrates the efficient synthesis of N-arylated products by employing a specialized photocatalyst in combination with nickel catalysis, utilizing readily available chloroarenes, including electron-rich haloarenes with low reactivity. The reaction system exhibits high selectivity and effectively suppresses the occurrence of dehalogenation side reactions, which are commonly observed in photocatalytic coupling processes.

Graphical abstract: Suppressing hydrodechlorination in PC–Ni cocatalyzed C–N and C–O coupling reactions

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Article information

Article type
Research Article
Submitted
18 Apr 2025
Accepted
05 Jul 2025
First published
07 Jul 2025

Org. Chem. Front., 2025, Advance Article

Suppressing hydrodechlorination in PC–Ni cocatalyzed C–N and C–O coupling reactions

B. Yang, H. Zhang, Y. Chen, J. Qu and Y. Kang, Org. Chem. Front., 2025, Advance Article , DOI: 10.1039/D5QO00660K

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