ZrCl4-promoted facile synthesis of indole derivatives

J. Tummatorn; M. P. Gleeson; S. Krajangsri; C. Thongsornkleeb; S. Ruchirawat

doi:10.1039/C4RA02158D

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ZrCl₄-promoted facile synthesis of indole derivatives†

J. Tummatorn,*^a M. P. Gleeson,^b S. Krajangsri,^a C. Thongsornkleeb^ac and S. Ruchirawat^ac

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* Corresponding authors

^a Chulabhorn Research Institute, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand
E-mail: jumreang@cri.or.th
Fax: +66 2 5538545

^b Department of Chemistry, Faculty of Science, Kasetsart University, 50 Phahonyothin Road, Bangkok, Thailand 10900

^c Program on Chemical Biology, Chulabhorn Graduate Institute, Center of Excellence on Environmental Health and Toxicology, CHE, Ministry of Education, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand

Abstract

Zirconium(IV) chloride effectively activates nitrogen (N₂) extrusion from aryl azidoacrylates followed by annulation to provide the desired indole products in moderate to good yields. The reaction proceeds at low temperature and in short reaction time and is applicable to a variety of substrates.

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Article information

DOI: https://doi.org/10.1039/C4RA02158D
Article type: Communication
Submitted: 12 Mar 2014
Accepted: 17 Apr 2014
First published: 18 Apr 2014

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RSC Adv., 2014,4, 20048-20052

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ZrCl₄-promoted facile synthesis of indole derivatives

J. Tummatorn, M. P. Gleeson, S. Krajangsri, C. Thongsornkleeb and S. Ruchirawat, RSC Adv., 2014, 4, 20048 DOI: 10.1039/C4RA02158D

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