Long-alkyl-chain-derivatized imidazolium salts and ionic liquid crystals with tailor-made properties †

Xinjiao Wang, Michelle Sternberg, Florian T. U. Kohler, Berthold U. Melcher, Peter Wasserscheid* and Karsten Meyer* A series of new 1,3-dialkylimidazolium salts with the general formula [CnCnIM][A] (for n1⁄4 12; A1⁄4 PF6 , OTf , NTf2 ; for n 1⁄4 10, 14, 16, and 18; A 1⁄4 BF4 , ClO4 ) has been synthesized. The [C12C12IM][A] salts are ionic liquids at room temperature, whereas all [CnCnIM][BF4] and [CnCnIM][ClO4] (n 1⁄4 10, 14, 16, 18) salts demonstrate a liquid crystalline phase at elevated temperatures that have a large mesophase window, which varies from 10 to 80 C with increasing alkyl chain length. In particular, [C10C10IM][BF4] shows liquid crystalline behavior at room temperature and therefore is potentially suitable for application as a pre-organized reaction medium in synthesis and catalysis. Viscosity studies of [C16C16IM][BF4] and the corresponding perchlorate salt demonstrate strong non-Newtonian viscosity behavior for the liquid crystalline state of these ionic liquids.


Introduction
Recently, research interest in ionic liquids (ILs) has been growing rapidly.This is mainly due to their unique properties, such as extremely low vapor pressures, wide liquidus ranges, high electric conductivities, wide electrochemical windows, and excellent tribological properties.These properties provide many possibilities for application as solvents and electrolytes. 1onic liquid crystals (ILCs) are dened as ionic species, exhibiting a liquid crystalline mesophase in a certain temperature range. 2 These materials hold great potential for catalytic applications by combining the benecial properties of both ionic liquids and ionic liquid crystals. 3Due to growing scientic interest, numerous thermotropic ionic liquid crystals have been studied in recent years and are summarized in a topical review by Axenov and Laschat. 4 Amongst reported ILs and ILCs, imidazolium-based salts are some of the most frequently studied examples, due in part to the developed synthetic routes that allow for convenient derivatization. 5,68][9] There are also reports on other derivatized imidazolium based cationic motifs, such as hydroxyl 10 or ester group derivatized alky chains 11,12 as well as simply protonated imidazolium ions, 13 aryl, [14][15][16][17] amide, 18,19 and vinyl functionalized imidazolium-based ionic liquid crystals. 20Recently, some unusual ILs and ILCs with a linear tris(imidazolium) core have been reported. 21lthough all of these functionalized imidazolium-based ILCs have shown interesting thermal properties, imidazolium-based ILCs comprised of linear, long alkyl chains are of special interest as they tend to form ordered structures with similarly structured olenic solvents.This presents potential for their application as "pre-organized ionic solvents" in catalysis. 2ecently, computer simulations were employed, indicating that chain length has an important effect on the formation of liquid crystalline phases. 22rganic transformations, stereochemically controlled by such ordered solvents, are an area of increasing interest and examples of rather "traditional" molecular liquid crystalline materials, such as 1-alkyl-substituted imidazolium salts À ), have been applied in Diels-Alder reactions. 13e previously reported the synthesis of symmetrically disubstituted imidazolium salts, namely 1,3-didodecylimida-  ] demonstrated that this system retains an ionic liquid crystalline phase; even aer immobilization on a porous silica-100 support. 24The catalytic organic reactions (e.g.olen dimerization) were carried out at room temperature to prevent catalyst decomposition at higher temperature.Thus, it was necessary for the reaction media composed of ionic liquid crystals to have a liquid crystalline phase at room temperature.Therefore, we recently turned our attention to the synthesis and characterization of a series of ILs, namely [C 12 C 12 IM][A] (where A ¼ I À , I 3 À , I 5 ).However, among these ILs, only the monoiodide salt [C 12 C 12 IM][I] exhibits a liquid crystalline phase in the temperature range from 40.4 to 88.5 C. 25 The effect of the respective anion on the solid-state molecular structures of these materials (e.g.degree of ordering, orientation of the alkyl chains with respect to the cationic imidazolium moiety, formation of polar and non-polar domains in the solid state, etc.) was studied by single-crystal X-ray diffraction methods and discussed previously. 25ttempting to improve the selectivity of catalytic reactions by creating a pre-organized, well-ordered reaction environment (e.g. for olen dimerization catalysis), we also studied the use of the newly synthesized ILCs, such as [C 12 C 12 IM][BF 4 ], in "Supported Ionic Liquid Phase" (SILP) catalysis.Due to the known thermal instability of self-activated catalysts, such as [(k 2 -P,Obis-diphenylphosphanylmonoxide)Ni(h 3 -methallyl)] + , 26 catalytic reactions with these complexes have to be carried out at room temperature.One example is the dimerization of ethylene with Ni-based SILP-type catalysts based on [C 2 MIM][FAP] (with FAP ¼ tris(pentauoroethyl)triuorophosphate anion). 27Therefore, we focused our subsequent research on nding conveniently tunable ionic liquid crystal solvents with liquid crystalline phases at room temperature.
Here, we report the synthesis and characterization of long alkyl chain substituted 1,3-dialkylimidazolium-based ionic liquids and ionic liquid crystals.The previously reported 1,3didodecylimidazolium salts were further modied by incorporating anions like [PF 6 ] À , [OTf] À , [NTf 2 ] À .In addition, the length of the even-numbered, symmetrically derivatized alkyl chains were varied from C 10 to C 18 for the [BF 4 ] À and [ClO 4 ] À imidazolium salts, in order to study the thermal behavior of these derivatives.The modication of the alkyl chain length at the functionalized cation was expected to result in an alteration of the melting point and in an increase of the viscosity and hydrophobicity of the liquids. 28n order to proof the purity of the bulk sample, all compounds were characterized by CHN elemental analyses as well as 1 H and 13 C NMR spectroscopy (see ESI †).All nal products were dried in vacuo at 70 C for 24 hours to remove traces of water.

Result and discussion
As expected, the solubility in polar organic solvents decreases with increasing chain length of the derivatized ILs.

Thermal behavior
The thermal properties of the newly synthesized compounds were studied by differential scanning calorimetry (DSC) and polarized optical microscopy (POM).Aer the initial heating and cooling cycle the observed transition temperatures were reproducible and constant for all subsequent cycles.Accordingly, the transition temperatures and enthalpies of the compounds are reported, starting from the second heating cycle of the DSC studies.The key results are summarized in Table 1 and 2.
Scheme 1 Synthesis of the dialkylimidazolium tetrafluoroborate and perchlorate salts.) clearly conrm all three compounds to be ionic liquids with melting points ranging from 40 C to approx.50 C (Table 1).However, these materials show no phase transition that could be attributed to a mesophase formation of a liquid crystalline material.Thus, among the very large variety of [C 12 C 12 IM][A]-based ionic liquids reported here and previously 23,25 with the anions À .These differences in melting point originate from a complex interplay of coulombic, H-bonding, and van-der-Waals interactions within the respective IL components.
Since liquid crystalline phases could not be observed in the ILs listed in Table 1 In Fig. 1, the phase transitions of the mesogenic imidazolium [BF 4 ] À and [ClO 4 ] À salts with different chain lengths are summarized.There is a notable increase in both melting and clearing points with increasing chain length in both salt series.The liquid crystalline mesophase range (temperature window) of both series increases with increasing alkyl chain length, which is mainly due to the stronger van-der-Waals interactions among the longer alkyl substituents of the cation.In addition, it is interesting to note that Rohini et al. report a series of 1,3dialkylimidazolium chloride and bromide salts with signicantly higher clearing temperatures, and thus larger mesophase ranges, than observed for the here reported [BF 4 ] À and [ClO 4 ] À salts.This may indicates that the anion, and thus electrostatic interactions, plays signicant role for the formation of mesophases.  ) determined by DSC (onset data, second heating cycle, Cr ¼ crystalline phase, SmA ¼ smectic-A phase, Iso ¼ isotropic phase) In order to monitor the ILs' thermal stability, the [BF 4 ] À salts were examined by thermogravimetric analysis (TGA).TGA thermograms of the tetrauoroborate salts, recorded at a rate of 10 K min À1 , show that the decomposition temperatures for To verify the aforementioned mesophases, polarized optical microscopy (POM) studies were performed on all of the [BF 4 ] À and [ClO 4 ] À salts that exhibit liquid crystalline characteristics.These compounds were heated to form an isotropic melt and then cooled at a rate of 5 K min À1 while being examined by crossed polarizers.In this case, the transition to the liquid crystalline phases could be followed.The observed focal coinic texture points to smectic-A phases.Birefringent textures were observed for the ILCs that exhibit mesophase as determined by DSC (Fig. 2 and ESI †).During cooling, POM images for [C 10 C 10 IM][BF 4 ] show a liquid crystalline phase below 12 C; and during heating in a narrow temperature range around 28 C. It is interesting to note that, during the second cooling cycle, when cooling to room temperature, this sample re-establishes its liquid crystalline phase not immediately but only aer a few minutes (Fig. 3).This is probably due to slow dynamics in the reorganization of this IL, such as cooperative linking of crystallization and complex conformation change in dense elds. 31,32scosity of [C 16    ILs behave like Newton uids. 28Increasing the shear rate, the viscosity remains constant.At higher temperatures a decrease in the viscosity is observed.This result is in good agreement with those we previously reported. 23Due to these results, we speculate that all other ILCs in this report are also non-Newtonian uids and hypothesize that non-Newtonian viscosity behavior is a typical property of ILCs with long alkyl chains, cf., C 12 -C 18 .

Mixtures of ILCs
In order to optimize and tailor the ILCs properties, e.g., the mesophase temperature window for synthetic applications, three different mixtures of the compounds [C 10 C 10 IM][BF 4 ] and [C 12 C 12 IM][BF 4 ] 23 with molar ratios of 1 : 3 (I), 1 : 1 (II), and 3 : 1 (III) were examined and their thermal properties were investigated by DSC.Interestingly, and entirely absent in each of the neat materials, the DSC measurements (Table 3) show a wide liquid crystalline phase for mixture I between 38.7 C and 55.7 C during heating, and between 53.0 C and 8.5 C during cooling, which is in an appropriate temperature range for many transition metal catalyzed reactions (Fig. 6).Notably, the equimolar and inverse 3 : 1 mixtures II and III, however, exhibit a mesophase only during cooling.

Conclusion
We     erlangen.de)at the University of Erlangen-Nuremberg.We thank Dr Susanne Hibler and Dr Henning Gieseler (Division of Pharmaceutics, Freeze Drying Focus Group, FAU) for assistance with the POM and the recording of some POM images.
zolium tetrauoroborate [C 12 C 12 IM][BF 4 ] and the corresponding perchlorate salt [C 12 C 12 IM][ClO 4 ].Both ILs show thermotropic liquid crystalline behavior over an extended temperature range from 50 C to 70 C and were the rst reported ILs to exhibit non-Newtonian viscosity behavior. 23Notably, differential scanning calorimetry, polarized optical microscopy, and temperature-programmed IR reection absorption spectroscopy performed on a mixture of 10 wt% Ni catalyst [NiCl 2 (C 12 C 12 IM) 2 ] in [C 12 C 12 IM][BF

SynthesisA
series of new C 12 alkyl chain derivatized imidazolium (IM) based ionic liquids, namely [C 12 C 12 IM][A] with A ¼ PF 6 À , OTf À , or NTf 2 À , were prepared by ion exchange from [C 12 C 12 IM]Cl and the corresponding ammonium or lithium salts.The 1,3dialkylimidazolium tetrauoroborate [C n C n IM][BF 4 ] and the corresponding perchlorate salt [C n C n IM][ClO 4 ] (n ¼ 10, 14, 16, 18) were prepared analogously to the previously reported synthesis of [C 12 C 12 IM][BF 4 ] and [C 12 C 12 IM][ClO 4 ] salts (Scheme 1). 23Anion metathesis was carried out in organic solvents and precipitation of the produced LiCl/NH 4 Cl/NaCl from organic solvents allowed for convenient separation by ltration.In addition, extraction of the ILs into CH 2 Cl 2 , and washing the solution with water, in which the ILs are insoluble, removed the remaining trace salt impurities.The imidazolium chloride starting materials were synthesized by alkylation of N-trimethylsilylimidazole with alkylchloride according to literature procedures. 29A straightforward procedure for the preparation of symmetrical 1,3-dialkylimidazolium salts was used: employing the highly reactive silylated imidazole and two equiv. of alkylhalide lead to quantitative quaternization and formation of trimethylsilyl chloride and bromide.Notably, the product ILs are solid compounds at RT, facilitating purication via recrystallization.
C 16 IM][BF 4 ] and [C 16 C 16 IM][ClO 4 ] In previous studies, we observedand reported for the rst timethat the ILCs [C 12 C 12 IM][BF 4 ] and [C 12 C 12 IM][ClO 4 ] exhibit strong non-Newtonian viscosity behavior (shear-thinning uid). 23In anticipation that other ILCs may also display non-Newtonian viscosity, we investigated the newly synthesized ILCs.Fig. 4 and 5 display the respective viscosity shear rate diagrams for [C 16 C 16 IM][BF 4 ] and the corresponding [ClO 4 ] À salt.The viscosity of both ILCs is dependent on the shear rate applied to the sample during the mesophase and the viscosity decreases drastically following an increase of the shear rate.For example, the viscosity of [C 16 C 16 IM][BF 4 ] abruptly decreases from 6.51 to 0.727 Pa s when the shear rate increases from 10 to 500 s À1 at 100 C. In fact, both new compounds are non-Newtonian uids during their mesophases.In the liquid phase, the

4 À , ClO 4 À
have synthesized a new series of 1,3-dialkylimidazolium salts [C 12 C 12 IM][A] (with A ¼ [PF 6 À ], [OTf À ], and [NTf 2 À ]) and [C n C n IM][A] (with n ¼ 10, 14, 16, 18; and A ¼ BF ).Three of these 1,3-didodecylimidazolium salts are ILs at room temperature, whereas the eight dialkylimidazolium tetra-uoroborate and perchlorate salts exhibit liquid crystalline phases over an adjustable and wide temperature range.Most notably, the mixture of [C 10 C 10 IM][BF 4 ] and [C 12 C 12 IM][BF 4 ] with a molar ratio of 1 : 3 shows a liquid crystalline phase at room temperature, rendering this mixture a suitable solvent for synthetic applications with the possibility of improved selectivity properties due to pre-organization of the reaction medium.Examination of the viscosity of [C 16 C 16 IM][BF 4 ] and [C 16 C 16 IM][ClO 4 ] as a function of shear rate revealed non-Newtonian viscosity behavior for both ionic liquids.From our results we also conclude that non-Newtonian viscosity behavior is likely a typical property of ILCs with long alkyl chains.

Table 1
Phase-transition temperatures (in C) and enthalpies of transition (DH in kJ mol À1