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A series of 2′-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 2–7 possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.

Graphical abstract: Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

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