Issue 44, 2021

Metal-free oxidative decarbonylative halogenation of fused imidazoles

Abstract

An efficient strategy has been developed for the deformylative halogenation of carbaldehyde imidazo-fused heterocycles in the presence of TBHP controlled by temperature. A convenient and sequential functionalization (C8 to C3) portrays the synthetic utility of the current method. N-Heterocycle benzamide products were also observed via the ring opening of imidazopyridines through the cleavage of C–C bond at high temperatures. Features of this method include temperature-controlled excellent regioselectivity, mild conditions and functional group tolerance.

Graphical abstract: Metal-free oxidative decarbonylative halogenation of fused imidazoles

Supplementary files

Article information

Article type
Communication
Submitted
17 Sep 2021
Accepted
19 Oct 2021
First published
20 Oct 2021

New J. Chem., 2021,45, 20551-20555

Metal-free oxidative decarbonylative halogenation of fused imidazoles

D. Singh, J. A. Tali, G. Kumar and R. Shankar, New J. Chem., 2021, 45, 20551 DOI: 10.1039/D1NJ04440K

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