Issue 30, 2013
From the journal:

Chemical Communications

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system†

Shlomit Guy,a   Dvir Rotem,a   Zvi Hayouka,a   Ronen Gabizon,a   Aviad Levin,b   Limor Zemel,a   Abraham Loyter,b   Danny Porath*ac  and  Assaf Friedler*ac  

* Corresponding authors

a Institute of Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel

b Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel

c The Harvey M. Kreuger Family Center for Nanosciene and Nanotechnology, Safra Campus, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
E-mail: danny.porath@mail.huji.ac.il, assaf.friedler@mail.huji.ac.il

Abstract

Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

Graphical abstract: Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

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Article information

DOI
https://doi.org/10.1039/C3CC40748A
Article type
Communication
Submitted
29 Jan 2013
Accepted
20 Feb 2013
First published
21 Feb 2013

Chem. Commun., 2013,49, 3113-3115

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Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

S. Guy, D. Rotem, Z. Hayouka, R. Gabizon, A. Levin, L. Zemel, A. Loyter, D. Porath and A. Friedler, Chem. Commun., 2013, 49, 3113 DOI: 10.1039/C3CC40748A

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