Issue 13, 2013
From the journal:

Chemical Communications

Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane†‡

Jose L. Garcia-Corderoa  and  Sebastian J. Maerkl*a  

* Corresponding authors

a Laboratory of Biological Network Characterization, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Station 17, Lausanne, Switzerland
E-mail: sebastian.maerkl@epfl.ch
Fax: +41 21 6937830
Tel: +41 21 6937830

Abstract

We report the flow-based in situ patterning of multiple proteins in microfluidic channels by simply tuning the actuation pressure of a microfluidic button-membrane. We show that a single button-membrane can pattern several concentric protein annuli, and we apply this patterning approach to a multiplexed immunoassay.

Graphical abstract: Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane

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Article information

DOI
https://doi.org/10.1039/C2CC37740C
Article type
Communication
Submitted
24 Oct 2012
Accepted
15 Nov 2012
First published
16 Nov 2012

Chem. Commun., 2013,49, 1264-1266

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Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane

J. L. Garcia-Cordero and S. J. Maerkl, Chem. Commun., 2013, 49, 1264 DOI: 10.1039/C2CC37740C

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