Ir(III)-Catalyzed Selective C-H Acylmethylation and Dicarbonylation of Indolizines with β-Ketosulfoxonium Ylides

Abstract

Herein, we report an Ir(III)-catalyzed regioselective C-H acylmethylation of indolizines with β-ketosulfoxonium ylides, enabling the efficient synthesis of C3-functionalized indolizine derivatives. By modifying the reaction conditions, a controllable Ir(III)-catalyzed dicarbonylation of the same substrates was also achieved. In this transformation, β-ketosulfoxonium ylides serve as a rare alternative to conventional oxophenacyl halides. Furthermore, this practical C(sp²)-H insertion strategy is scalable and can be further derivatized.