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Abstract | Cited by

Aminoglycoside 66-40C, co-produced with antibiotic sisomicin by Micromonospora inyoensis is unique among natural products, featuring a 16-membered macrocyclic bis-imine (X-ray) stable in aqueous solution and produced by quantitative self-assembly from self-selecting condensation of 6′-aldehyde monomers, in complex mixtures and in the presence of competing amine and aldehyde substrates.

Graphical abstract: Structural and kinetic study of self-assembling macrocyclic dimer natural product aminoglycoside66-40C and unnatural variants

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