Issue 21, 2012
From the journal:

RSC Advances

Biodegradable dendritic polymersomes as modular, high-relaxivity MRI contrast agents†‡

Ali Nazemi,a   Francisco Martínez,b   Timothy J. Schollb  and  Elizabeth R. Gillies*ac  

* Corresponding authors

a Department of Chemistry, Western University, 1151 Richmond St., London, Canada
E-mail: egillie@uwo.ca
Fax: +001 519-661-3022

b Department of Medical Biophysics and the Robarts Research Institute, Western University, 100 Perth Dr, London, Canada

c Department of Chemical and Biochemical Engineering, Western University, 1151 Richmond St., London, Canada

Abstract

A modular approach combining nanoscale components that each contribute to an enhancement in Gd(III) relaxivity is described here. Small molecule and dendritic alkyne derivatives of a Gd(III) complex were conjugated to the surfaces of biodegradable polymersomes resulting in ionic relaxivities of 10.6 mM−1 s−1 and 26.1 mM−1 s−1 respectively.

Graphical abstract: Biodegradable dendritic polymersomes as modular, high-relaxivity MRI contrast agents

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Article information

DOI
https://doi.org/10.1039/C2RA20886E
Article type
Communication
Submitted
09 May 2012
Accepted
07 Jul 2012
First published
06 Aug 2012

RSC Adv., 2012,2, 7971-7973

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Biodegradable dendritic polymersomes as modular, high-relaxivity MRI contrast agents

A. Nazemi, F. Martínez, T. J. Scholl and E. R. Gillies, RSC Adv., 2012, 2, 7971 DOI: 10.1039/C2RA20886E

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