Issue 30, 2012

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

Abstract

The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

Graphical abstract: Amphiphilic α-helix mimetics based on a benzoylurea scaffold

Supplementary files

Article information

Article type
Communication
Submitted
06 Feb 2012
Accepted
19 Mar 2012
First published
25 Apr 2012

Org. Biomol. Chem., 2012,10, 5780-5782

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

S. Thompson and A. D. Hamilton, Org. Biomol. Chem., 2012, 10, 5780 DOI: 10.1039/C2OB25273B

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