Synthesis of 4-trifluoromethyl-2H-chromenes via the reaction of 2-(trifluoroacetyl)phenols with vinyltriphenylphosphonium chloride

Abstract

Substituted on the benzene ring 4-CF₃-2H-chromenes have been prepared from substituted 2-(trifluoroacetyl)phenols and vinyltriphenylphosphonium chloride according to the Schweizer protocol in moderate to excellent yields. The influence of the type and the position of aromatic ring substituents on yields of 4-CF₃-2H-chromenes have been investigated. It has been shown that 4-CF₃-2H-chromenes are convenient precursors to 4-CF₃-coumarins.