Issue 92, 2012
From the journal:

Chemical Communications

Clear-cut observation of PNA invasion using nanomechanical DNA origami devices†‡

Takahiro Yamazaki,a   Yuichiro Aiba,§a   Kohei Yasuda,a   Yusuke Sakai,a   Yusei Yamanaka,b   Akinori Kuzuya,*b   Yuichi Ohyab  and  Makoto Komiyama§*a  

* Corresponding authors

a RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro, Japan
Fax: +81-3-5452-5209
Tel: +81-3-5452-5200

b Dept. Chem. Mater. Eng., Kansai University, 3-3-35 Yamate-cho, Suita, Japan
E-mail: kuzuya@kansai-u.ac.jp
Tel: +81-6-6368-0829

Abstract

Invasive binding event of PNA into DNA duplex was clearly observed both by atomic force microscope (AFM) imaging and electrophoretic mobility shift assay (EMSA) with the aid of nanomechanical DNA origami devices as ‘single-molecule’ visual probes, showing their potential as universal platform for the analysis of PNA invasion.

Graphical abstract: Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

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Article information

DOI
https://doi.org/10.1039/C2CC36358E
Article type
Communication
Submitted
31 Aug 2012
Accepted
04 Oct 2012
First published
05 Oct 2012

Chem. Commun., 2012,48, 11361-11363

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Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

T. Yamazaki, Y. Aiba, K. Yasuda, Y. Sakai, Y. Yamanaka, A. Kuzuya, Y. Ohya and M. Komiyama, Chem. Commun., 2012, 48, 11361 DOI: 10.1039/C2CC36358E

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