Issue 10, 2012
From the journal:

Chemical Communications

Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles†‡

Frédéric Loosli,a   David Alonso Doval,a   David Grassi,a   Pierre-Léonard Zaffalon,a   France Favargera  and  Andreas Zumbuehl*a  

* Corresponding authors

a Department of Organic Chemistry, University of Geneva, 1211 Geneva 4, Switzerland
E-mail: andreas.zumbuehl@unige.ch
Fax: +41 22 379 3215
Tel: +41 22 379 6719

Abstract

Two complementary artificial diether phospholipids were synthesized that can undergo a Cu(I)-catalyzed Huisgen–Sharpless click reaction. The resulting lipid can bridge the membranes of large unilamellar vesicles and cause their aggregation and ultimately their fusion.

Graphical abstract: Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles

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Article information

DOI
https://doi.org/10.1039/C2CC16827H
Article type
Communication
Submitted
03 Nov 2011
Accepted
23 Nov 2011
First published
24 Nov 2011

Chem. Commun., 2012,48, 1604-1606

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Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles

F. Loosli, D. A. Doval, D. Grassi, P. Zaffalon, F. Favarger and A. Zumbuehl, Chem. Commun., 2012, 48, 1604 DOI: 10.1039/C2CC16827H

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