Issue 1, 2012
From the journal:

Chemical Communications

Productivity enhancement of C[double bond, length as m-dash]C bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes†

Elisabetta Brenna,a   Francesco G. Gatti,*a   Daniela Monti,*b   Fabio Parmeggiania  and  Alessandro Sacchetti*a  

* Corresponding authors

a Politecnico di Milano, Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Piazza Leonardo Da Vinci 32, Milano, Italy
E-mail: francesco.gatti@polimi.it, alessandro.sacchetti@polimi.it
Tel: +39 02 23993070

b Istituto di Chimica del Riconoscimento Molecolare, C.N.R., Via Mario Bianco, 9, Milano, Italy
E-mail: daniela.monti@icrm.cnr.it
Tel: +39 02 28500038

Abstract

To overcome the usually low productivities of the C[double bond, length as m-dash]C bond bioreduction of α,β-unsaturated aldehydes we combined the in situ substrate feeding product removal (SFPR) technology with a cascade system comprising an isolated ene-reductase and a chemoselective alcohol dehydrogenase.

Graphical abstract: Productivity enhancement of C [[double bond, length as m-dash]] C bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes

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Article information

DOI
https://doi.org/10.1039/C1CC16014A
Article type
Communication
Submitted
27 Sep 2011
Accepted
20 Oct 2011
First published
09 Nov 2011

Chem. Commun., 2012,48, 79-81

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Productivity enhancement of C[double bond, length as m-dash]C bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes

E. Brenna, F. G. Gatti, D. Monti, F. Parmeggiani and A. Sacchetti, Chem. Commun., 2012, 48, 79 DOI: 10.1039/C1CC16014A

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