Novel optoelectronic metal organic framework material perylene tetracarboxylate magnesium: preparation and biosensing

Abstract

The pursuit for improving photoelectrochemical (PEC) performances of organic materials remains an urgent need. Here, we have proposed an envision of the preparation the metal–organic frameworks (MOFs) with arenes to realize high photo-to-current conversion efficiency and excellent PEC performances. Magnesium 3,4,9,10-perylene tetracarboxylic acid metal–organic frameworks (Mg-PTCA MOFs) were synthesized for the first time. The uniformly distributed and regular-shaped Mg-PTCA MOFs showed a much more stable and higher photocurrent than the single PTCA and its derivatives, which confirmed our hypothesis. A regenerated-biosensor was designed for microRNA analysis based on Mg-PTCA MOFs as a novel photoelectric material, target-triggered three-dimensional DNA Scaffold (3D-Sca) as an efficient signal amplifier, and gold nanoclusters (Au NCs) as quencher. The elaborately designed biosensor achieved ultrasensitive detection for miRNA 21 with a dynamic range from 10 aM to 10 pM and a detection limit of 2.8 aM. This biosensor showed good analytical performance in the extracts of different cancer cells, indicating the possibility for early diagnosis, timely staging assessment, and accurate prognostic judgment for diseases. The recommendable performances of Mg-PTCA MOFs highlight the significance of organic MOFs in PEC sensing.