Issue 3, 2011
From the journal:

MedChemComm

Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones†

Angela Scala,a   Massimiliano Cordaro,a   Antonino Mazzaglia,b   Francesco Risitano,a   Assunta Venuti,c   Maria Teresa Sciortinoc  and  Giovanni Grassi*a  

* Corresponding authors

a Dipartimento di Chimica Organica e Biologica, Università, Vill.S.Agata, Messina, Italy
E-mail: ggrassi@unime.it
Fax: +39 090 393897
Tel: +39 090 6765513

b ISMN-CNR c/o Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica Analitica, Università, Vill.S.Agata, Messina, Italy

c Dipartimento di Scienze della Vita “M. Malpighi”, Sezione Scienze Microbiologiche, Genetiche e Molecolari; Università, Vill.S.Agata, Messina, Italy

Abstract

A novel class of water soluble indole-3,4-diones has been synthesized and evaluated in vitro for antiviral activity against HSV-1. The results showed lack of cytotoxicity and significant antiviral activity. The cellular internalization efficiency and the antiherpetic effect were successfully increased by incorporation into nanoaggregates of an amphiphilic β-cyclodextrin.

Graphical abstract: Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones

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Article information

DOI
https://doi.org/10.1039/C0MD00190B
Article type
Concise Article
Submitted
27 Oct 2010
Accepted
02 Dec 2010
First published
20 Dec 2010

Med. Chem. Commun., 2011,2, 172-175

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Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones

A. Scala, M. Cordaro, A. Mazzaglia, F. Risitano, A. Venuti, M. T. Sciortino and G. Grassi, Med. Chem. Commun., 2011, 2, 172 DOI: 10.1039/C0MD00190B

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