Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes†
Abstract
A facile synthesis of various functionalized 3-substituted quinolin-2(1H)-ones through Ag(I) nitrate-catalyzed cyclization of o-alkynylisocyanobenzenes is described. The reaction allows rapid and convenient access to 3-substituted quinolin-2(1H)-one scaffolds in moderate to good yields.
- This article is part of the themed collection: Synthetic methodology in OBC