Issue 12, 2011
From the journal:

Chemical Communications

Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters†‡

Kaustabh Kumar Maiti,a   Animesh Samanta,b   Marc Vendrell,a   Kiat-Seng Soh,a   Malini Olivoacd  and  Young-Tae Chang*ab  

* Corresponding authors

a Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, 138667 Singapore

b Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543 Singapore
E-mail: chmcyt@nus.edu.sg
Fax: 65 6478 9957
Tel: 65 6478 8761

c Division of Medical Sciences, National Cancer Centre, 169610 Singapore

d School of Physics, National University of Ireland Galway, Ireland

Abstract

SERS nanotags have been prepared to accomplish the multiplex detection of cancer cells. Herein we evaluated the adequacy of lipoic acid-containing cyanine derivatives (Cy3LA and Cy5LA) to function as multiplex partners with a triphenylmethine Raman reporter (B2LA) under a single excitation wavelength. SERS experiments enabled the multiplex recognition of two different cancer cells with antibody-conjugated nanotags that were derivatized with optimized cyanine and triphenylmethine reporters.

Graphical abstract: Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters

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Article information

DOI
https://doi.org/10.1039/C0CC05265E
Article type
Communication
Submitted
30 Nov 2010
Accepted
15 Jan 2011
First published
09 Feb 2011

Chem. Commun., 2011,47, 3514-3516

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Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters

K. K. Maiti, A. Samanta, M. Vendrell, K. Soh, M. Olivo and Y. Chang, Chem. Commun., 2011, 47, 3514 DOI: 10.1039/C0CC05265E

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