Issue 16, 2011
From the journal:

Chemical Communications

DNA detection using enzymatic signal production and SERS†‡

Jennifer A. Dougan,a   Douglas MacRae,a   Duncan Grahama  and  Karen Faulds*a  

* Corresponding authors

a Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral St., Glasgow
E-mail: Karen.faulds@strath.ac.uk
Tel: +44 141 548 2507

Abstract

A novel DNA assay is demonstrated which relies on the production of a surface enhanced resonance Raman scattering (SERS) signal following sequence specific hybridisation and enzyme hydrolysis. This method achieves high sensitivity and specificity that can be applied to the detection of unlabelled duplex DNA and is the first step towards a SERS based signal amplification approach.

Graphical abstract: DNA detection using enzymatic signal production and SERS

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Article information

DOI
https://doi.org/10.1039/C0CC05216G
Article type
Communication
Submitted
26 Nov 2010
Accepted
22 Feb 2011
First published
15 Mar 2011

Chem. Commun., 2011,47, 4649-4651

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DNA detection using enzymatic signal production and SERS

J. A. Dougan, D. MacRae, D. Graham and K. Faulds, Chem. Commun., 2011, 47, 4649 DOI: 10.1039/C0CC05216G

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