P        1,P2-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs

Ivan B. Yanachkov; Edward J. Dix; Milka I. Yanachkova; George E. Wright

doi:10.1039/C0OB00542H

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P¹,P²-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs†

Ivan B. Yanachkov,*^a Edward J. Dix,^a Milka I. Yanachkova^a and George E. Wright^a

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* Corresponding authors

^a GLSynthesis Inc., One Innovation Dr, Worcester, MA, USA
E-mail: ivan.yanachkov@glsynthesis.com
Fax: +1 508 754 7075
Tel: +1 508 754 6700

Abstract

P ¹,P²-Diimidazolyl derivatives of pyrophosphate and halomethylene-bis-phosphonates have been synthesized and characterized, and the mechanism of their formation was studied. These reagents enable synthesis of dinucleoside tetraphosphates and tetraphosphonates conveniently and in high yields.

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Article information

DOI: https://doi.org/10.1039/C0OB00542H
Article type: Paper
Submitted: 05 Aug 2010
Accepted: 29 Sep 2010
First published: 17 Nov 2010

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Org. Biomol. Chem., 2011,9, 730-738

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P ¹,P²-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs

I. B. Yanachkov, E. J. Dix, M. I. Yanachkova and G. E. Wright, Org. Biomol. Chem., 2011, 9, 730 DOI: 10.1039/C0OB00542H

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Organic & Biomolecular Chemistry