Palladium-catalyzed regio- and enantio-selective trifluoromethylated allylic alkylation of diphenylphosphine oxides

Abstract

The first convenient method for the allylic alkylation of diphenylphosphine oxides catalyzed by palladium has been designed and developed, affording various chiral allylphosphine oxides bearing CF₃ groups with exclusive regio-selectivity and excellent enantioselective control. The reaction was performed in one pot under relatively mild reaction conditions using “easy-to-prepare” starting materials and relatively inexpensive chiral bis(phosphines) ligands. Further transformations of a representative product confirm the feasibility and potential applications of our synthetic strategies. In conclusion, this study provides a valuable method method for synthesizing chiral molecules bearing CF₃ and allylphosphine oxide.