Issue 11, 2024

Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

Abstract

A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid derivatives and N-phenyl glycine derivatives for the preparation of unnatural amino acids and peptides under base- and metal-free conditions has been reported. The reaction features a broad substrate scope and good yields. Besides, biomolecule compatibility and gram-scale experiments were performed to prove the potential application value of this protocol.

Graphical abstract: Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
05 Mar 2024
Accepted
07 Apr 2024
First published
17 Apr 2024

Org. Chem. Front., 2024,11, 3119-3123

Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

S. He, H. Fan, X. Zhang, M. Ye, J. Chen, J. Hou, T. Huang, L. Guo, G. Lv and Y. Wu, Org. Chem. Front., 2024, 11, 3119 DOI: 10.1039/D4QO00425F

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