From the journal:

Chemical Communications

A nitric oxide-boosting molecular agent to enhance mild-temperature photothermal therapy†

Xinhao Zhang,a   Wei Pan, ORCID logo *a   Jialin Kuang,a   Kaiye Wang,a   Na Li ORCID logo *a  and  Bo Tang ORCID logo *ab  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: panwei@sdnu.edu.cn, lina@sdnu.edu.cn, tangb@sdnu.edu.cn

b Laoshan Laboratory, Qingdao, P. R. China

Abstract

A nitric oxide (NO)-boosting molecular agent (CyHU) was developed for enhanced mild-temperature photothermal therapy (MPTT). This photothermal agent can specifically target mitochondria and efficiently produce NO, inhibiting adenosine triphosphate-dependent heat shock proteins, reversing tumor heat tolerance and ultimately achieving MPTT of cancer cells.

Graphical abstract: A nitric oxide-boosting molecular agent to enhance mild-temperature photothermal therapy

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Article information

DOI
https://doi.org/10.1039/D5CC00219B
Article type
Communication
Submitted
15 Jan 2025
Accepted
08 Feb 2025
First published
19 Feb 2025

Chem. Commun., 2025, Advance Article

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A nitric oxide-boosting molecular agent to enhance mild-temperature photothermal therapy

X. Zhang, W. Pan, J. Kuang, K. Wang, N. Li and B. Tang, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC00219B

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