One-pot preparation of dextran-capped gold nanoparticles at room temperature and colorimetric detection ofdihydralazine sulfate in uric samples

Abstract

We present a room-temperature strategy for the preparation of dextran-capped gold nanoparticles (AuNPs) in this contribution by employing dextran, which acts as both a reducing agent and a stabilizer, and thus well dispersed, uniform and biocompatible AuNPs could be successfully prepared in one pot. The investigations, including toxicological effect on cells and the capability of resisting aggregation in high ion medium, have demonstrated that the as-prepared AuNPs are biocompatible and stable even if in a medium of high ionic strength. In order to identify the practicability of the dextran-capped AuNPs, colorimetric detection of dihydralazine sulfate (DHZS) in uric samples based on the localized surface plasmon resonance (LSPR) of the AuNPs is made with the recovery in the range of 98.3–102.5%.