Issue 37, 2010
From the journal:

Chemical Communications

Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis†

Alessandro Pratesi,a   Chiara Gabbiani,b   Mauro Ginanneschia  and  Luigi Messori*b  

* Corresponding authors

a Laboratory of Peptide & Protein Chemistry & Biology, Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Firenze, Italy

b Laboratory of “Metals in Medicine” (METMED), Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy
E-mail: luigi.messori@unifi.it
Fax: +39 055 4573385
Tel: +39 055 4573388

Abstract

The tetrapeptide Ac-Gly-[Cys-Sec]-Gly-NH2, reproducing the C-terminal motif of the selenoenzyme thioredoxin reductase, was designed and synthesized, and its reactions with a few medicinally relevant gold(I,III) compounds investigated by ESI-MS. Remarkably, the main reaction products could be unambiguously identified providing valuable insight into the likely mechanisms of enzyme inhibition by gold compounds.

Graphical abstract: Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis

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Article information

DOI
https://doi.org/10.1039/C0CC01465F
Article type
Communication
Submitted
18 May 2010
Accepted
26 Jul 2010
First published
23 Aug 2010

Chem. Commun., 2010,46, 7001-7003

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Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis

A. Pratesi, C. Gabbiani, M. Ginanneschi and L. Messori, Chem. Commun., 2010, 46, 7001 DOI: 10.1039/C0CC01465F

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