Issue 45, 2024
From the journal:

Chemical Communications

Construction of a streptavidin-based dual-localized DNAzyme walker for disease biomarker detection†

Lingying Xia,ab   Junbo Chen, ORCID logo b   Xiandeng Hou, ORCID logo b   Rongxing Zhou ORCID logo *a  and  Nansheng Cheng ORCID logo *a  

* Corresponding authors

a Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
E-mail: zhourongxing@163.com, nanshengcheng@hotmail.com

b Analytical & Testing Center, Sichuan University, Chengdu, Sichuan 610064, China

Abstract

A dual-localized DNAzyme walker (dlDW) was constructed by utilizing multiple split DNAzymes with probes, and their substrates are separately localized on streptavidin and AuNPs, serving as walking pedals and tracks, respectively. Based on dlDW, biosensing platform was successfully constructed and showed great potential application in clinical disease diagnosis.

Graphical abstract: Construction of a streptavidin-based dual-localized DNAzyme walker for disease biomarker detection

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Article information

DOI
https://doi.org/10.1039/D4CC00912F
Article type
Communication
Submitted
26 Feb 2024
Accepted
22 Apr 2024
First published
29 Apr 2024

Chem. Commun., 2024,60, 5848-5851

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Construction of a streptavidin-based dual-localized DNAzyme walker for disease biomarker detection

L. Xia, J. Chen, X. Hou, R. Zhou and N. Cheng, Chem. Commun., 2024, 60, 5848 DOI: 10.1039/D4CC00912F

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