Nitroalkenes in directing group-assisted transition-metal-catalyzed C–H functionalization

Abstract

As an efficient and economical synthetic strategy, transition metal-catalyzed directing group-assisted C–H functionalization has flourished and been widely applied in the synthesis of various functional organic molecules. Among these, selective C–H functionalization involving alkenes has become a common method for constructing carbon–carbon bonds. Nitroalkenes not only exhibit significant pharmacological effects but also possess high reactivity, enabling the concise and rapid synthesis of diverse structural compounds. In recent years, selective C–H functionalization reactions involving nitroalkenes have attracted considerable attention from researchers. Reported works include C–H alkylation, [3+2] cyclization, [4+2] cyclization, and others. This article reviews the applications of nitroalkenes in C–H functionalization reactions, categorized by the reaction type.