Straightforward and fast access to electrochemical synthesis of selective brominated N-aryl glycine amides

Abstract

Brominated organic compounds (BOCs) serve as common organic building intermediates for various organic transformations. Herein, we report an electrochemical selective bromination of glycine derivatives with tert-butyl bromide as the source of bromine. Importantly, this protocol provides straightforward and fast access to brominated N-aryl glycine amides without exogenous oxidants and reductants; thus, this operationally convenient and efficient methodology could enable rapid library generation of brominated or dibrominated N-aryl glycine derivatives.