Microbial conversion of CO2 to organic compounds

Abstract

Microbial CO₂ fixation plays a crucial role in achieving cleaner production and addressing the energy crisis, as it facilitates the conversion of CO₂ into biofuels and biochemicals. However, to tap the full potential of microbial CO₂ fixation, it is important to identify the most efficient CO₂ fixation enzymes for incorporating CO₂ into organic compounds, design the most promising CO₂ fixation pathways for transmitting CO₂ into central carbon metabolism, and develop the most appropriate CO₂ fixation cell factories for outputting high-value bioproducts. Here, we summarize the latest advancements in microbial CO₂ fixation, and discuss prominent opportunities and barriers for improving the efficiency of microbial CO₂ fixation. In addition, we highlight trends and key challenges in microbial CO₂ fixation for future advancement of carbon-negative biomanufacturing.