Issue 78, 2022
From the journal:

Chemical Communications

An endoperoxide-containing covalent organic framework as a singlet oxygen reservoir for cancer therapy†

Fei Lu,‡b   Limeng Pan,‡a   Tong Wu,a   Wei Pan, ORCID logo a   Wen Gao,a   Na Li ORCID logo *a  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: lina@sdnu.edu.cn, tangb@sdnu.edu.cn

b Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, No 58, Renmin Avenue, Haikou 570228, P. R. China

Abstract

A porphyrin-based COF containing a dialkylnaphthalene derivative was constructed to deliver extracellular singlet oxygen (1O2) into cancer cells through the Diels–Alder/retro-Diels–Alder reaction between dialkylnaphthalene and 1O2 to realize light- and oxygen-independent oxidative damage for cancer therapy.

Graphical abstract: An endoperoxide-containing covalent organic framework as a singlet oxygen reservoir for cancer therapy

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Article information

DOI
https://doi.org/10.1039/D2CC04026C
Article type
Communication
Submitted
19 Jul 2022
Accepted
30 Aug 2022
First published
01 Sep 2022

Chem. Commun., 2022,58, 11013-11016

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An endoperoxide-containing covalent organic framework as a singlet oxygen reservoir for cancer therapy

F. Lu, L. Pan, T. Wu, W. Pan, W. Gao, N. Li and B. Tang, Chem. Commun., 2022, 58, 11013 DOI: 10.1039/D2CC04026C

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