Issue 1, 2007
From the journal:

Green Chemistry

Green synthesis of a temperature sensitive hydrogel

Márcio Temtem,a   Teresa Casimiro,a   João F. Mano*bc  and  Ana Aguiar-Ricardo*a  

* Corresponding authors

a REQUIMTE/CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
E-mail: aar@dq.fct.unl.pt
Fax: +351 212 948 385
Tel: +351 21 2949648

b 3B's Research Group—Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, Braga, Portugal
E-mail: jmano@dep.uminho.pt
Fax: +351 253604492
Tel: +351 253604497

c Department of Polymer Engineering, University of Minho, Campus de Azurém, Guimarães, Portugal

Abstract

A thermoresponsive hydrogel, poly(N-isopropylacrylamide), PNIPAAm, with possible applications in drug delivery, tissue engineering and as smart membranes with tuned permeability, was synthesised in supercritical carbon dioxide. A strategy of solvent-free impregnation/coating of polymeric surfaces with PNIPAAm is also suggested, in order to further extend the applications of membranes or porous bulky systems. In this work, in situ synthesis of PNIPAAm within a chitosan scaffold was tested as a proof of concept, in order to produce smart partially-biodegradable scaffolds for tissue engineering applications.

Graphical abstract: Green synthesis of a temperature sensitive hydrogel

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Article information

DOI
https://doi.org/10.1039/B603930H
Article type
Paper
Submitted
16 Mar 2006
Accepted
04 Oct 2006
First published
27 Oct 2006

Green Chem., 2007,9, 75-79

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Green synthesis of a temperature sensitive hydrogel

M. Temtem, T. Casimiro, J. F. Mano and A. Aguiar-Ricardo, Green Chem., 2007, 9, 75 DOI: 10.1039/B603930H

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