Issue 3, 2005
From the journal:

Natural Product Reports

Cucurbitacins and cucurbitane glycosides: structures and biological activities†

Jian Chao Chen,a   Ming Hua Chiu,*a   Rui Lin Nie,a   Geoffrey A. Cordellb  and  Samuel X. Qiuc  

* Corresponding authors

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P.R. China
E-mail: mhchiu@public.km.yn.cn
Fax: +86-871-5150227
Tel: +86-871-5223255

b Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, USA

c Department of Chemistry, Box 1134, Washington University, One Brookings Drive, St. Louis, MO, USA

Abstract

Covering: 1980 to August 2004

The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity. Structurally, they are characterized by the tetracyclic cucurbitane nucleus skeleton, namely, 19-(10→9β)-abeo-10α-lanost-5-ene (also known as 9β-methyl-19-norlanosta-5-ene), with a variety of oxygen substitutions at different positions. According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered.

Graphical abstract: Cucurbitacins and cucurbitane glycosides: structures and biological activities

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Article information

DOI
https://doi.org/10.1039/B418841C
Article type
Review Article
Submitted
15 Dec 2004
First published
04 Apr 2005

Nat. Prod. Rep., 2005,22, 386-399

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Cucurbitacins and cucurbitane glycosides: structures and biological activities

J. C. Chen, M. H. Chiu, R. L. Nie, G. A. Cordell and S. X. Qiu, Nat. Prod. Rep., 2005, 22, 386 DOI: 10.1039/B418841C

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