Issue 36, 2013
From the journal:

Organic & Biomolecular Chemistry

Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems†

Eliza James,a   Paul K. Eggers,a   Alan R. Harvey,b   Sarah A. Dunlop,c   Melinda Fitzgerald,c   Keith A. Stubbsd  and  Colin L. Raston*e  

* Corresponding authors

a Centre for Strategic Nano-Fabrication, The University of Western Australia, 35 Stirling Hwy, Crawley 6009, Australia

b School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Hwy, Crawley 6009, Australia

c School of Animal Biology, The University of Western Australia, 35 Stirling Hwy, Crawley 6009, Australia

d School of Chemistry and Biochemistry, The University of Western Australia, 35 Stirling Hwy, Crawley 6009, Australia

e Centre for NanoScale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA, Australia
E-mail: colin.raston@flinders.edu.au

Abstract

Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3+ head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.

Graphical abstract: Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

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Article information

DOI
https://doi.org/10.1039/C3OB41178H
Article type
Paper
Submitted
07 Jun 2013
Accepted
20 Jul 2013
First published
23 Jul 2013

Org. Biomol. Chem., 2013,11, 6108-6112

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Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

E. James, P. K. Eggers, A. R. Harvey, S. A. Dunlop, M. Fitzgerald, K. A. Stubbs and C. L. Raston, Org. Biomol. Chem., 2013, 11, 6108 DOI: 10.1039/C3OB41178H

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