Issue 13, 2011
From the journal:

Organic & Biomolecular Chemistry

Ready synthesis of free N-H 2-arylindoles via the copper-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization†

Huifeng Wang,a   Yaming Li,*a   Linlin Jiang,a   Rong Zhang,a   Kun Jin,a   Defeng Zhaoa  and  Chunying Duan*a  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, College of Chemical Engineering, Dalian University of Technology, Dalian, China
E-mail: ymli@dlut.edu.cn, cyduan@dlut.edu.cn
Fax: +86 411-84986295
Tel: +86 411-84986295

Abstract

A wide range of free N-H 2-arylindoles were synthesised via the copper(II)-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization. The convenience and atom economy of aqueous ammonia, and the low cost of the copper catalytic system make this protocol readily superior in practical application.

Graphical abstract: Ready synthesis of free N-H 2-arylindoles via the copper-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization

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Article information

DOI
https://doi.org/10.1039/C1OB05549F
Article type
Paper
Submitted
10 Mar 2011
Accepted
13 Apr 2011
First published
14 Apr 2011

Org. Biomol. Chem., 2011,9, 4983-4986

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Ready synthesis of free N-H 2-arylindoles via the copper-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization

H. Wang, Y. Li, L. Jiang, R. Zhang, K. Jin, D. Zhao and C. Duan, Org. Biomol. Chem., 2011, 9, 4983 DOI: 10.1039/C1OB05549F

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