We extended the proline-catalyzed asymmetric direct aldol reactions to the TBDMS protected hydroxyacetone. This important donor provides a ready access to optically active monoprotected 1,2-diol units simultaneously accompanied by stereoselective carbon-carbon bond formation in 40–90% yield and in up to 95% ee.
H. Liu, L. Peng, T. Zhang and Y. Li, New J. Chem., 2003, 27, 1159 DOI: 10.1039/B304019B
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