Issue 44, 2011
From the journal:

Chemical Communications

Functional MnO nanoclusters for efficient siRNA delivery†

Ruijun Xing,‡ab   Gang Liu,‡bc   Qimeng Quan,b   Ashwinkumar Bhirde,b   Guofeng Zhang,d   Albert Jin,d   L. Henry Bryant,e   Angela Zhang,b   Amy Liang,b   Henry S. Eden,d   Yanglong Hou*a  and  Xiaoyuan Chen*b  

* Corresponding authors

a Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, P.R. China
E-mail: hou@pku.edu.cn

b Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
E-mail: shawn.chen@nih.gov

c Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 63700, P.R. China

d Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA

e Laboratory of Diagnostic Radiology Research (CC), National Institutes of Health (NIH), Bethesda, USA

Abstract

A non-viral gene delivery nanovehicle based on Alkyl-PEI2k capped MnO nanoclusters was synthesized via a simple, facile method and used for efficient siRNA delivery and magnetic resonance imaging.

Graphical abstract: Functional MnO nanoclusters for efficient siRNA delivery

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC15408G
Article type
Communication
Submitted
31 Aug 2011
Accepted
22 Sep 2011
First published
12 Oct 2011

Chem. Commun., 2011,47, 12152-12154

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Functional MnO nanoclusters for efficient siRNA delivery

R. Xing, G. Liu, Q. Quan, A. Bhirde, G. Zhang, A. Jin, L. H. Bryant, A. Zhang, A. Liang, H. S. Eden, Y. Hou and X. Chen, Chem. Commun., 2011, 47, 12152 DOI: 10.1039/C1CC15408G

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