Issue 13, 2006
From the journal:

Organic & Biomolecular Chemistry

Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors

Hilaire V. Kemami Wangun,a   Albert Härtl,a   Trinh Tam Kietb  and  Christian Hertweck*ac  

* Corresponding authors

a Dept. Biomolecular Chemistry, Leibniz-Institute for Natural Products Research and Infection Biology, Beutenbergstr. 11a, Jena, Germany
E-mail: christian.hertweck@hki-jena.de
Fax: INT+3641-656705
Tel: INT+3641-656700

b Centre of Biotechnology, Vietnam National University, 144 Xuan Thuy Street, Hanoi, Vietnam

c Friedrich-Schiller-University, Jena

Abstract

By bioassay-guided isolation, phenylpropanoid-derived polyketides, including an unusual 5-methyl-3(2H)-furanone derivative (inotilone) with potent cyclooxygenase (COX) and xanthone oxidase (XO) inhibitory activities were obtained from the fruiting body of the mushroom Inonotus sp.

Graphical abstract: Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B604505G
Article type
Paper
Submitted
28 Mar 2006
Accepted
09 May 2006
First published
24 May 2006

Org. Biomol. Chem., 2006,4, 2545-2548

Permissions

Request permissions

Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors

H. V. Kemami Wangun, A. Härtl, T. Tam Kiet and C. Hertweck, Org. Biomol. Chem., 2006, 4, 2545 DOI: 10.1039/B604505G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements